ABSTRACT
This study was undertaken to determine the effect of Centella asiatica aqueous extract (CAEt) on nociception; experimental diabetes and hyperlipidemia in mice and rats. The extract was administered orally and the effects of different doses of the extract on nociception in mice; on blood glucose; glucose-6-phosphatase; and serum and tissue lipids in rats with alloxan-induced diabetes were studied. Diclofenac and chlopropamide were used as standard drugs for nociception and diabetes; respectively. The doses of extract administered were 150; 300; 500 mg/kg body weight. The data obtained indicated that the aqueous extract of Centella asiatica exhibited anti-nociceptive activity in mice. Results of the anti-diabetic study indicated that the extract suppressed the elevated blood glucose. In anti-hyperlipidemic study; lipid levels didn't change in diabetic rats treated with CAEt. These findings show that the extract possesses anti-nociceptive and anti-diabetic activities
Subject(s)
Alloxan , Analgesics , Centella , Diabetes Mellitus , Hypoglycemic Agents , Mice , Plant Extracts , RatsABSTRACT
Laportea ovalifolia (Scham and Thonn) is widly use in Cameroon for the treatment of diabetes mellitus. The present study was designed to evaluate the antidiabetic and hypolipidaemic effects of aqueous extract of Laportea ovalifolia aerial part in normal and alloxan diabetic rats. Diabetes was induced by intraperitoneal injection of alloxan (150 mg kg -1 body weight). The treatment was given for 2 weeks. After the treatment a significant reduction was observed in fasting serum glucose levels in the treated diabetics rats. L. ovalifolia treatment showed considerable lowering of serum total cholesterol; triglycerides; LDL cholesterol; T.C/HDL.C and an increase in HDL cholesterol in the treated diabetic group. These results suggest that the Laportea ovalifolia aqueous extract of the aerial part possesses antidiabetic and hypolipideamic effects in alloxan-induced diabetic rats