Dermatophytes and other Skin Mycoses Found in Featherless Broiler Toe Webs

Background: Feartherless broilers which are produced by a complex breeding programme from feathered parents carrying the Sc-gene; dissipates excessive body heat under hot and humid conditions. It has high body weight; and grows very rapidly when compared with standard commercial broilers. Their toe webs are bigger than standard commercial broilers; and could harbor fungi which can cause infections where there is the opportunity. Objectives: To isolate and identify the presence of fungi in toe webs of featherless broilers. Methods: A total of 50 featherless broilers' toe webs samples were examined microscopically for the presence of fungi. The samples were examined microscopically and culturally using standard microbiological techniques. Results: The fungi recovered were as follows. Microsporum gypseum 9 (22); Trichophyton mentagrophytes var. mentagrophytes 5 (12); Microsporum gallinae 3 (7); Aspergilus flavus 10 (24); Fusarium sp 6 (15); Alternaria alternata 3 (7) Scopulariopsis brevicaulis 2 (5) and Candida albicans 3 (7); Conclusion: The featherless broilers' toe webs habour fungi which cause mycotic skin disease and cannot be regarded as ordinary normal flora of toe webs

Antifungal Activity of Erigeron floribundus (Asteraceae) from Cote d'Ivoire; West Africa

Purpose: Erigeron floribundus is a reputed medicinal plant used in Cote d'Ivoire; West Africa for the treatment of skin disorders. The aim of this study was to evaluate the antifungal activity of this plant against fungi from human origin. Method: Dichloromethane; methanol 80and aqueous extracts from the leaves with stem were tested for their antifungal activity against 7 strains of dermatophytes (Epidermophyton floccosum; Microsporum canis; M. gypseum; M. langeronii; Trichophyton mentagrophytes; T. rubrum; T. soudanense) and one strain of the filamentous fungus; Scopulariopsis brevicaulis. The assays were performed using the agar dilution method at serial concentrations ranging from 2 to 0.06 mg/ml. Result: Only the dichloromethane extract exhibited an activity against Microsporum canis and a broad spectrum of good antifungal activity against all the remaining fungi tested.Conclusion: To the best our knowledge; this is the first report of the antifungal activity of Erigeron floribundus against a wide range of dermatophytes; including Microsporum langeronii and Trichophyton soudanense; the most frequent dermatophytes in Cote d'Ivoire. E. floribundus might be potential sources for improved traditional medicines or new antidermatophyte agents for the treatment of dermatomycoses

Synthesis of some 1;2;5-trisubstituted benzimidazole Analogs as possible Anthelmintic and Antimicrobial agents

A novel series of 1;2;5-trisubstituted benzimidazole derivatives was synthesized by coupling 2-mercapto-5-methoxybenzimidazol-1-acetic acid with several amino acid methyl ester hydrochlorides/dipeptides/tripeptides using dicyclohexylcarbodiimide (DCC) as the coupling agent and triethylamine (TEA) as the base. All newly synthesized compounds were characterized by spectral as well as elemental analysis and evaluated for their biological potential. Compounds 5; 8 and 12 were found to exhibit potent anthelmintic activity against M. konkanensis; P. corethruses and Eudrilus sp. in comparison to standard drug - mebendazole. Moreover; compounds 7; 9 and 13 possessed potent antifungal activity against C. albicans and compounds 4 and 10 displayed good activity against pathogenic bacteria P. aeruginosa. Gram negative bacteria were found to be more sensitive in comparison to gram positive bacteria towards the newly synthesized benzimidazolopeptide analogs

Aspects epidemiologiques et cliniques des onychomycoses a Dakar

Pendant une periode de 3 ans; 240 sujets ont ete examines pour une affection de l'ongle au Laboratoire de Parasitologie et de Mycologie du CHU Le Dantec. Parmi eux; 76 avaient une mycose confirmee; soit un taux de prevalence globale de 31;7 pour cent. Les prelevements positifs ont permis d'isoler des levures (57;8 pour cent) appartenant surtout a l'espece C. albicans; des dermatophytes (35;5 pour cent) representes par Tricophyton rubrum et Trychophyton soudanense et enfin des moisissures (0;1 pour cent) appartenant au genre Aspergillus et Penicillum. Ce sont les femmes; surtout des menageres; agees de 21 a 30 ans qui sont les plus touchees par l'onychomycose; qui siege surtout au niveau des doigts. Ce travail montre que l'onychomycose n'est pas une affection rare a Dakar. Ceci devrait inciter certaines personnes a risque a porter des gants pendant le travail

Efficacy of lamisil in the treatment of onychomycosis of the finger nail

Fungal infection of the nail is commonly encountered dermatological problem in Nigeria. It is observed to be more frequently encountered in female patients who for cosmetic reasons seek dermatological services readily than males. A strong association between tinea pedis and onychomycosis has also been established. The most commonly encountered dermatophyte in the infection of the nail is trichophyton rububrum; which is known to be very difficult to treat and to re-occur very often