ABSTRACT
Purpose: Erigeron floribundus is a reputed medicinal plant used in Cote d'Ivoire; West Africa for the treatment of skin disorders. The aim of this study was to evaluate the antifungal activity of this plant against fungi from human origin. Method: Dichloromethane; methanol 80and aqueous extracts from the leaves with stem were tested for their antifungal activity against 7 strains of dermatophytes (Epidermophyton floccosum; Microsporum canis; M. gypseum; M. langeronii; Trichophyton mentagrophytes; T. rubrum; T. soudanense) and one strain of the filamentous fungus; Scopulariopsis brevicaulis. The assays were performed using the agar dilution method at serial concentrations ranging from 2 to 0.06 mg/ml. Result: Only the dichloromethane extract exhibited an activity against Microsporum canis and a broad spectrum of good antifungal activity against all the remaining fungi tested.Conclusion: To the best our knowledge; this is the first report of the antifungal activity of Erigeron floribundus against a wide range of dermatophytes; including Microsporum langeronii and Trichophyton soudanense; the most frequent dermatophytes in Cote d'Ivoire. E. floribundus might be potential sources for improved traditional medicines or new antidermatophyte agents for the treatment of dermatomycoses
Subject(s)
Anti-Bacterial Agents , Arthrodermataceae , Asteraceae , ErigeronABSTRACT
This study was designed to evaluate the toxicity of the aqueous extract of Aspilia africana leaves. Oral doses of 500 mg/kg and 1000 mg/kg were administered for 28 days to rats after every 2 days for sub-acute toxicity. For acute toxicity; 5 doses of 2; 4; 8; 12 and 16g/Kg body weight were investigated in mice. The control groups consisted of mice or rats administered with distilled water. The signs of toxicity fluctuated lightly from one mammal to another throughout the experiment. The liver; kidneys and heart weight of rats revealed no significant differences between the test groups and the control. The results indicated that the medium lethal dose (LD50) was found to be greater in females than males with an average of 6.6g/Kg body weight for both sexes. Regardless of the significant differences observed at certain points in some biochemical parameters (ALT; AST; ALP; Creatinine and Glutathione); none showed any linear dose responsiveness. On the other hand; most of the parameters investigated were found to be gender dependent. These results suggested that A Africana can be classified among substances with low toxicity
Subject(s)
Asteraceae/toxicity , Pharmaceutical Preparations , Plant LeavesABSTRACT
This study was designed to evaluate the toxicity of the aqueous extract of Aspilia africana leaves. Oral doses of 500 mg/kg and 1000 mg/kg were administered for 28 days to rats after every 2 days for sub-acute toxicity. For acute toxicity; 5 doses of 2; 4; 8; 12 and 16g/Kg body weight were investigated in mice. The control groups consisted of mice or rats administered with distilled water. The signs of toxicity fluctuated lightly from one mammal to another throughout the experiment. The liver; kidneys and heart weight of rats revealed no significant differences between the test groups and the control. The results indicated that the medium lethal dose (LD50) was found to be greater in females than males with an average of 6.6g/Kg body weight for both sexes. Regardless of the significant differences observed at certain points in some biochemical parameters (ALT; AST; ALP; Creatinine and Glutathione); none showed any linear dose responsiveness. On the other hand; most of the parameters investigated were found to be gender dependent. These results suggested that A Africana can be classified among substances with low toxicity