ABSTRACT
Extracts of Cardiospermum gradiflorum and Cardiospermum halicacabumwere screened for antimicrobial activities against Candida albicans; Escherichia coli; Staphylococcus aureus; Bacillus subtilis and Streptococcus viridans using the agar diffusion method. The two plants produced antimicrobial activities against all the test organisms. C. grandiflorum exhibited higher antimicrobial activity than C. Halicacabum. S.aureus was the most resistant to the extract of C. Gradiflorum among the organisms assayed while E. coli was the most resistant to the leaf extract of C. halicaca. The mimumum inhibitory concentration of the extracts ranged between 35mg/ml and 50mg/ml. Cardiospermum Gradiflorum could be a more effective antimicrobial agent than Cardiospermum halicaca