ABSTRACT
Moringa oleifera (LAM), arbre tropical à usages multiples, constitue de nos jours une nouvelle ressource alimentaire et économique pour les pays du Sud. Ces feuilles sont faciles d'accès et très riches en protéines, en vitamines et en minéraux. Elles sont de plus en plus utilisées dans des projets luttant contre la malnutrition. Cependant, le goût, la présentation et la qualité de ces produits demeurent une préoccupation majeure nécessitant des adaptations innovantes. L'objectif de cette étude était d'étudier la comprimabilité des poudres de feuilles de Moringa oleifera en améliorant le goût avec des matières premières locales et facilement accessibles comme la poudre de pulpe de Andansonia digitata. Les propriétés physico-chimiques et les tests pharmacotechniques ont permis de contrôler la qualité des poudres, des comprimés et orienter le choix du procédé de fabrication. Cinq (5) types de formulations (F1 à F5) ont été réalisés et les comprimés ont été fabriqués par compression après granulation par la voie sèche. Les comprimés des formulations F4 et F5 ont donné de meilleures propriétés pharmacotechniques selon les recommandations de la pharmacopée Européenne 6.0. L'association des deux poudres offre une alternative pour la fabrication de comprimés à croquer avec un goût acceptable
Subject(s)
Adansonia , Burkina Faso , Chemical Phenomena , Moringa oleifera , Quality ControlABSTRACT
BACKGROUND:The relatively little resistance to quinine globally has led to an increase in its use in P. falciparum malaria especially in multi-drug resistant strains.OBJECTIVE:To evaluate the physicochemical and equivalency of three brands of quinine sulphate tablets available in South Western region of Nigeria.METHODS:The pharmaceutical and chemical equivalence of three brands of quinine sulphate tablets were assessed through the evaluation of some biopharmaceutical parameters and active drug content. RESULTS:All the brands complied with the official specification for uniformity of weight. Two of the brands (A & B) gave similar crushing strengths while the third brand (C) gave a much lower value. Similarly all the brands complied with the official specification of disintegration test but the obtained values were statistically different (p<0.05). The T(70) obtained from the dissolution rate profile was less than 45 minutes for the three brands, although A and B were not statistically different but C was statistically from A and B. The quinine content of brands B and C are within the official specification however brand A with percentage content of 110±1.3%w/w, is above the specification while it is statistically different from the other brands. CONCLUSION:Brands B and C could be regarded as chemical equivalent, but they are not biopharmaceutical equivalents, on the other hand, brands A and B may be regarded as biopharmaceutical equivalents but not chemical equivalent
Subject(s)
Antimalarials/chemistry , Chemical Phenomena , Malaria, Falciparum , NigeriaABSTRACT
Background:Granules of extracted cellulose from cocoa pod husk (CPHC) and powder extract from the crude cocoa pod husk (CPHP) were characterized physicochemically for possible applications as pharmaceutical excipients.Aim: To determine the percentage content of cellulose and powder extracts from the crude cocoa pod husk as excipients in pharmaceutical formulation of solid dosage forms (tablets).Method: Cellulose was obtained from dried and sized cocoa pod shell through a chemical process involving washing; filtration and bleaching at 40-60oC with 3.5nitric acid; sodium hypochlorite and sodium hydroxide then whitened with the use of hydrogen peroxide. The cellulose and powder extracts obtained were subjected to physicochemical tests (bulk density; true density; flowability; moisture content; sorption and hydration capacity).Results: The cellulose extract yield was approximately 31. Both the cellulose and powder extract exhibited low bulk density; high porosity; high true density indicating poor packing characteristics of their granules but good compressibility properties. The powder extract (CPHP) had high moisture contents. The angle of repose of the cellulose is lower than that of the powder extract (340 and 440 respectively). Both materials (cellulose and powder) had high hydration capacity (3.02 to 3.07) comparable to standard disintegrants (micro crystalline cellulose and maize starch of 3.06 and 3.05 respectively).Conclusion: The yield of about 31indicates a high content of cellulose in cocoa pod husk. The extracted cellulose (CPHC) and the powder extract (CPHP) upon physicochemical characterization indicated their relevance as disintegrants in direct compression and wet granulation pharmaceutical formulation methods respectively