Big data analytics for integrated infectious disease surveillance in sub-Saharan Africa

Background: Infectious disease outbreaks are common in sub-Saharan Africa (SSA). Consequently, integrated public health surveillance has become increasingly essential for the region. Health surveillance systems enable early detection and monitoring of emerging and re-emerging disease outbreaks, thus informing preparedness and response measures. However, complex and intertwined factors obstruct a successful integrated public health surveillance in SSA, with dire consequences. Objectives: The objective of this article was to establish how big data analytics can be used to enhance integrated infectious disease surveillance and response in SSA. Method: The Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) was used to identify and select relevant articles. A total of 10 studies that addressed the article's objective were selected. Results: Findings reveal several barriers to the application of big data analytics for public health surveillance in SSA. These include the absence of regulatory and data governance frameworks for big data management in healthcare, disparities in digital health infrastructure across SSA's healthcare systems, and the digital and analytical skills required for data capture and interpretation. The development of regulatory frameworks is essential for the ethical application of analytical technologies such as artificial intelligence. Conclusion: This article's contributions emphasise the need for comprehensive strategies for the application of big data analytics for public health surveillance, as well as addressing barriers to its successful application by highlighting the requirements for an integrated infectious disease surveillance and response system in SSA. Contribution: The article contributes to the body of knowledge on the interplay between the public health space and digital health interventions by emphasising the beneficial applications of big data analytics for surveillance and response to address emerging and re-emerging infectious disease outbreaks in the health systems of sub-Saharan Africa.

Communicable and non-communicable diseases diagnosis and treatment service availability at primary health care Units during COVID-19 outbreak in Ethiopia

BACKGROUND: Non-communicable diseases (NCDs) pose a substantial global health challenge, resulting in an annual death toll of over 15 million individuals aged 30 to 69. Ethiopia, categorized as COVID-19 vulnerable, grapples with NCD treatment challenges. This study aims to assess disease service availability at primary health units in Ethiopia during the pandemic. METHODS: A facility-based cross-sectional study was conducted from October to December 2021 across regions, encompassing 452 facilities: 92 health centers, 16 primary hospitals, 344 health posts, and 43 districts. Facility selection, based on consultation with regional health bureaus, included high, medium, and low performing establishments. The study employed the WHO tool for COVID-19 capacity assessment and evaluated services for various diseases using descriptive analysis. RESULTS: Results reveal service disruptions in the past year: hospitals (55.6%), health centers (21.7%), districts (30.2%), and health posts (17.4%). Main reasons were equipment shortages (42%), lack of skilled personnel (24%), and insufficient infection prevention supplies (18.8%). While tuberculosis treatment was fully available in 23% of health posts and malaria services in 65.7%, some health centers lacked HIV/AIDS, cardiovascular, mental health, and cervical cancer services. Most communicable and noncommunicable disease diagnoses and treatments were fully accessible at primary hospitals, except for cervical cancer (56.3%) and mental health (62.5%) services. CONCLUSION: Significant gaps exist in expected services at primary health units. Improving disease care accessibility necessitates strengthening the supply chain, resource management, capacity building, and monitoring systems.

Prevalence of risk factors of non-communicable diseases among adolescents in Uasin Gishu County, Kenya

Objective: This study aimed to establish the prevalence of risk factors (tobacco use, alcohol abuse, physical inactivity and unhealthy diet) of non-communicable diseases (NCDs) among secondary school students in a developing country. Design: A descriptive cross-sectional study using the self-administered WHO STEP-wise questionnaire for chronic disease risk factor surveillance on adolescents attending secondary schools in Kenya. The study was carried out in the period between May and July 2018. Setting: Ten secondary schools were randomly selected in Uasin Gishu County, using stratified proportional sampling. Subjects: A total of 1,281 students assented to participate in the study. The mean age of the participants was 16.6 (SD±1.509) with the majority being female (55%, n=704) Results: The prevalence of alcohol abuse was 30.8%(n=394) with males having statistically significant higher rates than females (p < 0.05) and 6.8% of the participants were smokers. Of those that reported smoking, 60.9% were between 15-17 years of age. Adequate intake of three (3) servings of vegetables per day was seen in 13.5% of the respondents and 54.4% (n=697) of the total sample were found to be physically inactive. Conclusion: The prevalence of NCD risk factors among secondary school students in Uasin Gishu County is significant. As a result, health education and targeted interventions should be implemented in order to promote a healthy lifestyle which is important in preventing NCDs in future.

The COVID-19 pandemic in sub-Saharan Africa: The significance of presumed immune sufficiency

A novel coronavirus known as severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was first reported in China in 2019 and later ignited a global pandemic. Contrary to expectations, the effect of the pandemic was not as devastating to Africa and its young population compared to the rest of the world. To provide insight into the possible reasons for the presumed immune sufficiency to coronavirus disease 2019 (COVID-19) in Africa, this review critically examines literature published from 2020 onwards on the dynamics of COVID-19 infection and immunity and how other prevalent infectious diseases in Africa might have influenced the outcome of COVID-19. Studies characterising the immune response in patients with COVID-19 show that the correlates of protection in infected individuals are T-cell responses against the SARSCoV-2 spike protein and neutralising titres of immunoglobin G and immunoglobin A antibodies. In some other studies, substantial pre-existing T-cell reactivity to SARS-CoV-2 was detected in many people from diverse geographical locations without a history of exposure. Certain studies also suggest that innate immune memory, which offers protection against reinfection with the same or another pathogen, might influence the severity of COVID-19. In addition, an initial analysis of epidemiological data showed that COVID-19 cases were not severe in some countries that implemented universal Bacillus Calmette­Guerin (BCG) vaccination policies, thus supporting the potential of BCG vaccination to boost innate immunity. The high burden of infectious diseases and the extensive vaccination campaigns previously conducted in Africa could have induced specific and non-specific protective immunity to infectious pathogens in Africans.

Challenges of contact tracing during COVID-19 pandemic response in a tertiary hospital in Northwestern Nigeria

Background: Contact tracing is a traditional pillar of infectious disease control, especially for illnesses involving direct transmission from person to person, such as COVID-19. Several challenges have arisen from COVID-19 contact tracing activities, particularly in low-resource settings. These include refusal of positive clients to disclose their close contacts, difficulties in conducting risk assessment for contacts traced, among others. Objectives: To explore the activities and identify challenges of contact tracing during COVID -19 pandemic response in a tertiary hospital in Northwestern Nigeria from May, 2020 to March, 2021. Methodology: Amixed method approach was done with quantitative secondary data analysis of COVID-19 contacts traced, and qualitative assessment through Key Informant Interviews (KII) of Ahmadu Bello University Teaching Hospital staff involved in COVID-19 outbreak response during the period. Results: Atotal of 2,249 clients were tested for COVID-19, of which 925 (41.1%) were healthcare workers. The identified challenges included problems with contact identification, delay in notification of results, refusal to disclose contacts by cases, contacts refusing to allow risk assessment, and health workers being overwhelmed by the task of contact tracing. Conclusion: Challenges identified include refusal of cases to disclose their contacts, overwhelming number of contacts, and delay in notification of results. There is need to institute contact tracing protocols to mandate cases to disclose their contacts, train more manpower to reduce the burden of contact tracing, and improve the notification of results.

Support for the response to COVID-19 in Uganda: contribution of the global health security program at Makerere University's Infectious Diseases Institute

Background: Outbreaks are occurring at increasing frequency and they require multisectoral and multi-stakeholder involvement for optimal response. The Global Health Security Agenda is a framework that governments and other stakeholders can use to strengthen countries' capacities to prevent, detect and respond to outbreaks but there are few examples of academic programs using this approach. Methods: This is a narrative review of contributions of Makerere University through the Global Health Security Program at the Infectious Diseases Institute (IDI). Information was sourced from peer-reviewed publications and grey literature highlighting work done between 2017 - 2021. Results: Aligned to GHSA, IDI made contributions to strengthen national and subnational capacities for biosafety and biosecurity, sample collection and transportation, electronic disease surveillance, infection prevention and control, case management prior to COVID-19 that were subsequently used to support response efforts for COVID-19 in Uganda. Conclusion: The IDI Global Health Security program provides a model that can be used by institutions to deliberately develop capacities relevant to outbreak preparedness and response.

Mastering your fellowship: Part 3, 2022

The series, 'Mastering your Fellowship', provides examples of the question formats encountered in the written and clinical examinations, Part A of the Fellowship of the College of Family Physicians of South Africa (FCFP SA) examination. The series is aimed at helping family medicine registrars (and their supervisors) prepare for this examination.Keywords: family physicians; FCFP (SA) examination; family medicine registrars; postgraduate training; national exit examination; infectious diseases.

A retrospective review of rabies post-exposure prophylaxis queries, South Africa, 2016­2019

Background: The National Institute for Communicable Diseases (NICDs) of South Africa (SA) provides technical support to healthcare workers (HCWs) with regard to infectious diseases through the NICD clinician hotline. Queries to the hotline are often about rabies prophylaxis. An analysis of these queries may help to identify knowledge gaps amongst HCWs regarding prevention of rabies in humans in SA. Methods: A retrospective descriptive review was conducted to analyse rabies post-exposure prophylaxis (PEP) queries received by the NICD from 01 January 2016 to 31 December 2019. Results: A total of 4655 queries were received by the NICD clinician hotline for the study period, of which 2461 pertained to rabies PEP (52.87%). The largest number of calls were placedby HCWs (n = 2313/2437; 94.9%). Queries originated mainly from Gauteng (n = 912/2443; 37.3%) and KwaZulu-Natal (n = 875/2443; 35.8%) provinces. A total of 50 different types of animals were related to exposures involving humans. Dogs (67.7%) and cats (11.8%) were the animals most frequently reported and exposure category III was most common (88.6%). Approximately equal numbers of callers were advised active management of administering rabies PEP and conservative management of withholding PEP. This did not seem to be affected by the exposure category related to the call. Conclusion: This analysis shows the ongoing demand by HCWs for technical support regarding patient management following potential exposure to rabies. Gaps in HCWs rabies knowledge provide unique learning points on guiding training to achieve the goal of eliminating dog-mediated human rabies deaths by 2030.

Impact of COVID-19 on blood donation and supply in Africa

No abstract available

A scoping review to identify the type and effect of hand hygiene interventions on the reduction of infectious diseases (including COVID-19) in preschool children

Background. Proper handwashing can reduce the burden of diseases related to hand hygiene (HH) and so contribute reducing under-5 mortality. Preschoolers can benefit from HH interventions by the burden of disease and absenteeism being reduced. Objective. To perform a scoping review of literature to assess the types and effectiveness of HH interventions at preschools, with a view to providing a guideline for appropriate interventions for South African facilities. Methods. A literature search was conducted through the PubMed database to identify relevant studies. An iterative screening process to focus the review allowed for information on the type and effectiveness of interventions to be collated. An updated PubMed search was conducted to determine whether any interventions related to COVID-19 at preschools could be included. Results. No additional studies relating to COVID-19 were found. Of the 305 studies identified during the initial search, only 12 fitted the specific search criteria. Of these, 10 studies showed improvements in HH-related indicators following the interventions. Only two studies used health education as an intervention, whereas the others included the supply of HH products (to varying extents) as part of the intervention. Conclusion. HH interventions appear successful in reducing diseases spread by poor HH, improving general HH practices and reducing absenteeism among preschoolers. Studies using innovative, entertaining methods of educating children have shown to be successful in improving handwashing techniques and decreasing microbial growth on children's hands. HH interventions are suggested as an effective measure to improve HH during the COVID-19 pandemic.

Tuberculosis: a review

Tuberculosis (TB) is an infectious disease of bacterial origin caused by Mycobacterium tuberculosis (MTB), which is a member of the Mycobacterium tuberculosis complex (MTBC). Mycobacterium tuberculosis(MTB) is also known as Koch bacillus or tubercle bacillus. The burden of TB has remained a problem due to factors that have promoted and fostered transmission, including increasing resistance of the disease to the most effective first-line anti-TB drugs. There is the need for cases to be diagnosed early and managed appropriately by skilled and knowledgeable health care workers (HCWs). Reports of low level of knowledge concerning TB among some HCWs during the 2016 hajj prompted this review which was prepared using articles on TB searched on various websites of international institutions like the world health organization (WHO), the United States center for disease control and prevention (CDC) and PubMed. Here we provide a brief history of tuberculosis and an overview of the current literature on, basic classification of, immunology, public health concerns and treatment guidelines of TB. The information provided will be a useful guide for HCWs and the general public

Healthcare workers' adherence to infection prevention and control guidelines for respiratory infectious diseases: A rapid qualitative evidence synthesis

COVID-19 spreads easily between people who are in close contact, or through coughs and sneezes. As the number of cases continues to increase, healthcare workers (HCWs) are notably at risk as a result of frequency of contact with suspected cases or infected people. Use of infection prevention and control (IPC) strategies by HCWs is therefore important. We summarise the evidence from a rapid Cochrane qualitative evidence synthesis by Houghton et al. on barriers and facilitators to HCWs' adherence to IPC guidelines for respiratory infectious diseases

Federation of infectious diseases societies of southern Africa guideline: Recommendations for the detection, management and prevention of healthcare-associated candida auris colonisation and disease in South Africa

Candida auris has been detected at almost 100 South African hospitals, causing large outbreaksinsome facilities, and this pathogen now accounts for approximately 1 in 10 cases of candidaemia. The objective of this guideline is to provide updated, evidence-informed recommendations outlining a best-practice approach to prevent, diagnose and manage C.auris disease in public- and private-sector healthcare settings in South Africa. The 18 practical recommendations cover five focus areas: laboratory identification and antifungal susceptibility testing, surveillance and outbreak response, infection prevention and control, clinical management and antifungal stewardship

An observational study of safe and risky practices in funeral homes in South Africa

Background. Funeral home personnel are at risk of exposure to infectious hazards. The high prevalence of infectious diseases in South Africa means that these workers and family members of deceased individuals are vulnerable to infection if proper safety measures and equipment are not used. Objectives. To collect observational information on funeral industry practices in order to assess the safety of handling corpses and exposure to risk that could result in disease transmission. Methods. A cross-sectional study was conducted across two locations from August to October 2015. Funeral homes in Klerksdorp and Soweto were approached. The study team did facility assessments and observed preparation practices, focusing on safety equipment, personal protective equipment (PPE) and contact with hazardous materials. Interviews with funeral home personnel and relatives of the deceased were also conducted. Results. Of the funeral homes, 23.0% (20/87) agreed to participate. A median of 5 personnel (interquartile range 4 - 8) were employed per facility. It was observed that not all PPE was used despite availability. Gloves, aprons and face masks were most commonly worn, and no personnel were observed wearing boots, gowns or plastic sleeves. Funeral homes were located near food outlets, schools and open public spaces, and not all had access to proper biohazardous waste disposal services. Of 5 family members who were interviewed for the study, none reported being willing to partake in the funeral preparation procedure. Conclusions. There is a need to standardise the use of safety equipment, waste disposal methods and location designation in the funeral industry

Trends of blood-borne infectious diseases in a rural blood donation center of southeast Gabon (Koula-Moutou)

Introduction: blood-borne pathogens such as human immunodeficiency virus (HIV), hepatitis B and C (HBV and HCV) viruses and Treponema pallidum remain a major public health problem in sub-Saharan Africa. The purpose of this study was to assess the frequency and clinical implications of HIV, HBV, HCV and Treponema pallidum markers in blood donors in a rural area of Southeast Gabon (Koula-Moutou) from 2012 to 2017.Methods: hepatitis B surface antigen (HBsAg), anti-HIV, anti-HCV and anti-Treponema pallidum antibodies were screened using rapid diagnostic tests. Results: of a total of 5,706 blood donors, 1,054 (18.5%) were seropositive for at least one infectious marker and 59 (5.6%) had serologic evidence of multiple infections. The overall seroprevalence of HIV, HBsAg, HCV, and syphilis was 3.1%; 5.9%; 6.2% and 3.3%, respectively. HIV, syphilis and HCV distributions were associated with neither the sex nor the age of the donors. Only HBsAg seroprevalence was significantly higher in donors of the age group 26-35 years old compared to donors of the age group 36-45 years (OR = 1.43 (95% CI: 1.01-2.04), P = 0.045). There was a significant increase in the frequencies of HIV and syphilis and a regression of HBsAg and HCV among blood donors.Conclusion: this study presents the epidemiology of the main pathogens detected in blood donors in a rural area in Gabon. We found that the overall distribution of transfusion transmitted infectious diseases were lower than those observed in the general population but could be underestimated due to the use of rapid diagnostic tests (RDTs) in the screening process of the blood donations

Bacteriocidal activity of handwash products and soaps sold in Port Harcourt, Nigeria ­ An in vitro study

BACKGROUND: Hand hygiene is still noted as one of the most important factors essential for control of infectious diseases particularly in hospital settings and soap and water is still of essence, especially when hands are visibly soiled. The use of medicated handwash products is becoming more widespread. These products sometimes claim a better efficacy than plain soap and water. This study set out to determine trends in antibacterial activity of medicated and non-medicated locally sold soap products and bacteriocidal activity of these products against commonly encountered clinical pathogens (Staphylcoccus aureus, Klebsiella pneumoniae and Escherichia coli).METHODS: Antibacterial activity of 4 handwash and 3 bodywash products was determined using the Agar-well diffusion, minimum inhibitory concentration and minimum bacteriocidal concentration tests.RESULTS: At 100% product concentration, both non-medicated handwash products (Pears and Cussons) gave zones of inhibition ranging from 8 ­ 17 mm and 9 ­ 12 mm respectively, while the medicated products resulted in zones of inhibition ranging from 23 ­ 30 mm and 17 ­ 29 mm. Liquid bodywash products were less inhibitory with 'no inhibition' observed in 66.7% (18/27) of cases than 11.1% (4/36) of cases of the handwash. All handwash products had bacteriocidal activity against all three test strains, while for the bodywash products, no bacteriocidal activity was observed in 4 cases.CONCLUSION: This study highlights the important role soaps particular the medicated versions play in hand hygiene. Further studies involving human volunteers and time-kill assays would be necessary to provide a more complete story of the effectiveness of these products in infection control

Manifestations cliniques des patients vivant avec le VIH à l'ère de la trithérapie hautement active au service des maladies infectieuses du CHU Yalgado Ouedraogo (Burkina Faso)

Dans le but d'améliorer la prise en charge des patients vivant avec le VIH, nous avons mené cette étude avec pour objectif de décrire les manifestations cliniques des PVVIH hospitalisées dans le service des Maladies Infectieuses du CHU Yalgado Ouédraogo.Patients et méthode : Il s'agit d'une étude prospective qui s'est déroulée du 1er janvier 2013 au 28 février 2014. Ont été inclus tous les patients VIH positifs connus ou dépistés dans le service, sous traitement ARV ou non, admis dans le service. Le traitement et l'analyse des données collectées ont été faits à l'aide du logiciel Epi info version 3.5.1.Résultats : La prévalence hospitalière de l'infection à VIH était de 22%. Soixante-cinq pour cent des malades étaient de sexe féminin (sex ratio = 1,9). L'âge moyen des patients était de 40 ans ± 11. Quatre-vingt-onze pour cent (91%) des patients étaient positifs au VIH1 ; Le taux de CD4 médian était de 78 cellules/ml avec des extrêmes de 8 à 718 cellules/mm3. Soixante-sept pour cent (67%) des patients dépistés dans le service étaient au stade IV de la classification de l'OMS. Trente-six pour cent (36%) des patients avaient au moins une double comorbidité associée au VIH. Un état général altéré et une gastro-entérite étaient les signes cliniques présentés par la plupart des malades. La tuberculose, le paludisme grave, les mycoses digestives et les co-infections VIH/VHB étaient les plus fréquemment diagnostiqués. Trente pour cent (30%) des patients sous ARV étaient en échec thérapeutique. La létalité était de 23,6%, plus importante chez les patients sévèrement immunodéprimés (P = 0,01). Conclusion : Les manifestations cliniques sont caractérisées par un polymorphisme clinique. Le dépistage et la prise en charge précoce des pathologies fréquemment diagnostiquées chez les patients vivant avec le VIH contribueront à réduire leur mortalité