Prevalence of dermatophytosis among primary school children in Oke-Oyi community of Kwara state

Background: Dermatophytic infections have been known to impact negatively on health and well-being of children. This study was undertaken to determine the prevalence; clinical types as well as the etiologic organisms of dermatophyte infection among primary school children aged 5-16 years in Oke-Oyi community in Kwara state. Materials and Methods: A 4-months descriptive cross-sectional survey was carried out among 602 children aged 5-16 years in Oke-Oyi community; in Kwara state. Results: The prevalence of clinically suspected dermatophytoses lesion was 29.9(180/602). Dermatophyte accounted for 5.0(30/602) on Sabouraud dextrose agar culture; while non-dermatophyte molds represent majority of isolate i.e.; 15.4(93/602). Tinea capitis is the commonest clinical type; followed by Tinea coporis and then Tinea pedis. Multiple infections are noted in nine respondents. Three species of dermatophytes belonging to only two of the three genera of dermatophytes were responsible for human infection in the area studied; of which Trichophyton mentagrophyte is the commonest; followed by Microsporum audouinii and Trichophyton verucossum. Among the non-dermatophytes; Aspergillus fumigatus and Candida albicans predominate. Conclusion: This study demonstrates that the prevalence of dermatophytoses in the school studied was significant. Control efforts should target this vulnerable group to reduce its prevalence

Clinical Characteristics of Dermatophytosis among Children in A Nigeria Population; the Role of HIV/AIDS

Background: Dermatophytosis is a common superficial mycosis. It affects virtually every child at one stage or the other; but the disease may be more frequent in individuals with immunocompromising conditions.The typical characteristic of the rash is an annular; popular rash with a healing centre and an active periphery that may have an erythematous base and it occurs in different parts of the body.Aims:To elicit the clinical characteristics of dermatophytosis among children with HIV/AIDS. Methods:Two hundred each of HIV sero-positive and sero-negative children were evaluated for dermatophytosis (and its clinical types) and the possible role of HIV was examined.Results: Thirty-two (16) seropositive and 24(12) sero-negative children had dermatophytosis (P = 0.086).Tinea capitis was the most prevalent among the sero-positive and was the only type seen among the sero-negative subjects. Dermatophytosis was significantly more prevalent among those with more advanced clinical stage of HIV (p = 0.000). Children in 5 - 12 year age bracket were more affected in both groups. Conclusion: Tinea capitis was the most frequent type of dermatophytosis in the study; followed by tinea corporis. Children in 5 - 12 year age bracket were more affected in both groups. Occurrence of dermatophytosis was significantly influenced by the stage of HIV disease but not by HIV status

An open non-comparative pilot study of the safety and efficacy of oral fluconazole in the treatment of dermatophyte infections in Nigeria

In an non-comparative study to assess the efficacy and safety of oral fluconazole in superficial fungal diseases of the skin; 82 adult Nigerian patients (58 males and 24 females) with clinical and mycological diagnosis of dermatomycoses were enrolled for the trial. Sixty-five patients completed the trial and each of them received a daily dose of 50mg fluconazole for a period of 4 weeks. An overall 90 per cent cure rate was observed in patients with other forms of dermatomycoses and 80 per cent for patients with pityriasis versicolor. The drug was well tolerated by all the patients and very few side effects were noticed