ABSTRACT
Introduction :Une forte consommation des benzodiazépines (BZDs) a été remarquée en dehors parfois des règles de recommandations de prescription, ce qui rend leur consommation un problème majeur de santé publique. La présente étude a eu pour objectif d'évaluer la prescription et l'usage des BZDs dans la ville de Sidi Bel-Abbès. Méthodes-Il s'agissait d'une étude descriptive transversale réalisée du 01 Février 2018 au 30 Juin 2018 évaluant la prescription et l'usage des BZDs dans la ville de Sidi Bel-Abbès au moyen d'un questionnaire distribué aux patients de l'hôpital psychiatrique, du service de psychiatrie du CHU et aux pharmaciens d'officine.Le critère de jugement principal était l'évaluation de la prescription et de l'utilisation des BZDs dans cette ville. La saisie et l'analyse des données ont été réalisées par le logiciel SPSS. Résultats-Au total, 353 patients traités au moins par une BZD ont été inclus dont 178 hommes. Le taux de prescription des BZDs était de 1.10, des jeunes (59,77 %) et des personnes mariées (60,34%) constituaient les consommateurs privilégiés. La prescription était l'apanage des psychiatres, en monothérapie (07,42%), la molé cule la plus fréquemment prescrite était le Bromazépam (31,07%) et la prise noc turne était la plus importante (49,01%). Les BZDs étaient utilisées pour combattre l'insomnie (25,21%), l'anxiété (16,43%), pour une durée de plus d'une année (57,79 %). Conclusion-La prescription et l'utilisation des BZDs dans la ville de Sidi Bel-Abbès s'est avérée importante. L'insomnie et l'anxiété constituaient les principales raisons de leur utilisation, et le Bromazépam était la molécule la plus fréquemment utilisée .
Introduction-A high consumption of benzodiazepines (BZDs) has been noticed so metimes outside the rules of prescription recommendations, which makes their consumption a major public health problem. The present study aimed to evaluate the prescription and use of BZDs in Sidi Bel-Abbès city. Methods-: This was a descriptive cross-sectional study carried out from February 01st, 2018 to June 30th, 2018 evaluating the prescription and use of BZDs in of Sidi Bel-Abbès by means of a questionnaire distributed to patients from the psychiatric hospital, the CHU psychiatry department and community pharmacists. The primary endpoint was the assessment of the prescription and use of BZDs in this city. Data entry and analysis were performed using SPSS software. Results-A total of 353 patients treated with at least one BZD were included, including 178 men. The prescription rate of BZDs was 1.10, young people (59.77%) and married people (60.34%) were the privileged consumers. The prescription was the prerogative of psychiatrists, in monotherapy (07.42%), the molecule most frequent ly prescribed was Bromazepam (31.07%) and night intake was the most important (49.01%). BZDs were used to combat insomnia (25.21%), anxiety (16.43%), for a period of more than a year (57.79%). Conclusion-The prescription and use of BZDs in Sidi Bel-Abbès has proven to be important. Insomnia and anxiety were the main reasons for their use, and Bromazepam was the most molecule frequently used.
Subject(s)
Humans , Male , Female , Adolescent , Adult , Middle Aged , Aged , Anxiety , Benzodiazepines , Bromazepam , Substance-Related Disorders , Therapeutic Uses , Prescription Drugs , Long Term Adverse Effects , Sleep Initiation and Maintenance Disorders , Dosage Forms , Algeria , Medical OveruseABSTRACT
Purpose: To formulate the extracts of the stem bark of Alstonia boonei; an important antimalarial herb; into tablet dosage form. Methods: Tablets were formulated using direct compression and wet granulation methods. The mechanical properties of the tablets were assessed using crushing strength and friability and the crushing strength:friability ratio (CSFR) while drug release properties were evaluated using disintegration and dissolution times. Results: There were statistically significant (p0.01) differences in the CSFR values and drug release properties of A. boonei tablets prepared by both methods. The differences depended on the type and concentration of excipient and binder employed in the formulation. Conclusions: The method of preparation of the A. boonei tablets needs to be carefully selected to ensure the production of tablets with adequate bond strength to withstand the rigours of handling and at the same time release the active compound (s) for biological action
Subject(s)
Alstonia/chemistry , Antimalarials , Dosage Forms , Plant ExtractsABSTRACT
Purpose: The objective of this study is to investigate whether the drug release profile of a multi-unit dose form consisting of fast and slow release components can be predicted from the release profiles of their components by simple summation. Method: The fast release component consisted of conventional granules of theophylline made by wet massing the drug powder with starch mucilage (20w/v). The slow release component consisted of matrix granules of the drug made by triturating the drug powder with melted carnuba wax (i.e. melt granulation). Each type of granules was compressed to tablets of weight 100; 150 or 200mg. To form the multi-unit dosage tablets of drug content 300mg each; the conventional and matrix granules were mixed in the ratio 1:2; 1:1 and 2:1; and compressed. The tablets were subjected to dissolution test and from the experimental release curve the prompt release (mp) in the first 1h; the maximum release (m ) and the time to attain it (t ) were obtained. Result: For a given composition of the multi-unit dose tablets; the theoretical release curve was obtained by summation of the release from each component at the different time intervals. The mp values of the theoretically estimated release curves were generally higher; while their t values were generally shorter than the corresponding values for the experimental curves. Conclusion: The indication is that drug release from the multi-unit dose tablets was more retarded than could be theoretically estimated. Apparently; the two components interfere with each other's release