ABSTRACT
A pharmaceutical formulation is aimed at ensuring drug delivery at the site of action in order to produce the desired therapeutic effect. The design of a pharmaceutical formulation must reflect the chemical reactivity of the drug substance as well as those of any other substances that are used in the formulation. Standardized manufacturing procedures which conform to accepted codes of Good Manufacturing Practices are prerequisites for the preparation of pharmaceutical formulations for optimal drug delivery. Drug formulations produced by such methods are expected to have the desired bioavailability characteristics for pharmacotherapy. The different types of pharmaceutical formulations usually prepared for administration by various routes are aimed at achieving the most appropriate drug delivery system for each drug. When necessary; special drug delivery systems are designed to achieve this objective. Advances in biotechnology has led to production of labile substances for use as drugs in therapy and this has created new challenges in the development of novel drug delivery systems. [abstract terminated]
Subject(s)
Chemistry , Drug Administration Routes , Drug Delivery Systems , TechnologyABSTRACT
Parmi les plantes medicinales les plus utilisees en Tunisie; figure le thymus capitatus; plus connu sous le nom de thym. L'administration pendant deux semaines d'un decocte de thym ameliore la fonction renale et entraine des baisses significatives des concentrations renales en exalates; en urates; en phosphates et en calcium. Ces baisses semblent etre provoquees par les chutes des excretions urinaires de l'acide oxalique et urique et par l'elevation de la zinciurie. Une legere amelioration de la fonction renale a ete mise en evidence egalement chez les animaux traites. Ces resultats laissent supposer que le thym pourrait etre une plante de choix dans la prevention et peut etre aussi; dans le traitement des lithiases renales