Comparative drug therapy problems and pharmacists' intervention in selected health facilities in Ogun State

Background - Regular medication reviews will reduce the occurrence of Drug Therapy Problems (DTPs). This study set out to identify, document DTPs and evaluate the impact of pharmacists´ interventions in selected health facilities. Methods - The study was carried out simultaneously at two tertiary and two secondary hospitals in Ogun States. Pharmacists were trained to document all identified DTPs in prescriptions and impacts of pharmacists' interventions for six months using the documentation form, PCNE V5.01. Data was analyzed and presented as frequencies with test of significance of main parameters. Results ­ One hundred and four (104) DTPs were reported in all the health facilities but with no significant difference in occurrence at the two hospital levels. Commonly occurring DTPs were drug choice problems (35.6%), dosing problems (33.9%), adverse drug reaction (22.8%), drug use problems (4.23%) and drug interactions (1.69%). Most proposed interventions (77.0%) were approved by prescribers with (77.2%) resolution of DTPs in tertiary hospitals. Conclusion- There was no significant difference in occurrence of DTPs in the hospitals but there was higher incidence of non-allergic ADR, contraindication, duration of drug use and duplication of drugs at the secondary level. Acceptance rate of proposed interventions by physicians was high (77.2%) confirming that pharmacists' intervention in rational pharmacotherapy is valuable

Les complications cutanees de la chimiotherapie antitumorale dans les services de dermatologie et cancerologie du CHU de Treichville

L'etude prospective portant sur 100 cas de complications cutanees de la chimiotherapie anticancereuse observee en 12 mois avec une prevalence de 18;18pour cent fait ressortir un accroissement regulier de l'emploi des chimiotherapies. Le developpement de la chimiotherapie oblige a mieux connaitre les effets secondaires de la chimiotherapie anticancereuse. Parmi ceux-ci; les complications cutanees tiennent une place importante. En effet; les medicaments anticancereux sont avant tout actifs sur les cellules en division rapide; et de ce fait la peau represente une excellente cible. Au cours de notre etude prospective; nous avons decrit et evalue les aspects cliniques des complications cutanees de la chimiotherapie et la toxicite des medicaments anticancereux inherentes a l'utilisation des protocoles usuels de la chimiotherapie anticancereuse. Sur l'ensemble des protocoles; nous avons observe une predominance des toxicites phaneriennes : alopecie (45pour cent); muqueuse (32pour cent); cutanee (23pour cent). Il n'a pas ete note de toxicite grave a type de syndrome de LYELL ni de deces. Selon notre etude; cette toxicite est liee a des facteurs tels t~ue l'age; le terrain; le choix des protocoles; le nombre de cures; la compliance. L'action pour l'amelioration de la prise en charge des malades atteints de cancer en matiere de chimiotherapie devrait s'orienter vers: -une identification des complications les plus frequentes. -en fonction du nombre de cures. -le suivi de tout cancer doit concerner: ola muqueuse ; oles cheveux (phaneres) ; ola peau. Cependant; les toxicites cutaneo-muqueuses et phaneriennes observees au cours de notre etude n'ont jamais constitue un facteur limitant du traitement