Role of Eosinophilsin parasitic Infections

Eosinophilia; a pronounced increase of eosinophils in the blood or tissues; occurs in numerous important circumstances; like allergic diseases; parasitic infections; and cancer. Helminthic parasites are usually the common parasitic infections witch cause eosinophilia apart from two enteric protozoans; Isospora belli and Dientamoeba fragilis. Infection with helminthes parasites produces immune effector responses and in a reaction to various stimuli; eosinophils are recruited from the circulation into inflammatory foci; where they modulate immune responses via sequences of mechanisms. The defence against organisms that are too large to be phagocytosed; particularly parasitic helminthes seems to be the primary role of eosinophils. In this article; we will discuss some of the biological features of eosinophils and their role in parasitic infections

Churg Strauss Syndrome: a Review

Background:Churg Strauss syndrome is a medical condition of unknown aetiology characterized by asthma; eosinophilia and finally vasculitis involving small vesselsin the limbs and nasal sinuses and the lungs. The purpose of this review is to highlight the natural history of this condition; the pathogenesis; clinical features andtreatment modalities available and the prognosis. Methods:Literature on the subject was reviewed using manual library search; articles in journals; internet search and conference abstracts. Results : Churg Strauss syndrome has been reported to be predominantly common in middle aged individuals in their middle age of life with a history of new onset or worsened asthma. The condition has a male predisposition. Prior to the advent of steroid therapy this condition invariably leads to death; but since theintroduction of prednisolone therapy and other immunosuppressive therapy; the outlook has improved for sufferers and long term survival has been seen. Conclusion: Suspicion of this condition should be based on a good history; physical examination and laboratory investigations and diagnosis based on the criteria that has been drawn by the American College of Rheumatology