ABSTRACT
Objective: Multifocal epithelial hyperplasia (MEH) or Heck's disease is a rare benign disorder caused by Human Papilloma Virus (HPV). It is characterized by multiple soft well demarcated nodules of the oral mucosa. They are commonly seen in buccal, labial and lingual mucosa. However, tonsilar and gingival lesions have also been reported. A detailed clinical history, examination and histopahological review is needed to arrive at a diagnosis. The aim of this report is to show the successful treatment of MEH using Salicylic acid and Zinc supplement. Case Report. Two cases of a 5year old Hausa girl and 7-year-old Hausa boy with a widespread oral lesion of 8 months and 1-year duration respectively. The diagnosis of the case reported were based on clinical evaluation and histopathological investigation. The presence of multiple painless pink nodules and papules on the lips, buccal mucosa and the gingiva as well as histological presence of koliocytes and mitosoid seen on hematoxylin and eosin slide led to the diagnosis of MultifocalEpithelial Hyperplasia. Conclusion: We reported 2 cases of MEH, a rare benign oral mucosa lesion in a 5-year-old Hausa female and a 7year old Hausa male in North-West Nigeria who presented with 8 months and 1-year history of widespread oral mucosa lesion respectively and was treated successfully using salicylic acid and zinc supplement
Subject(s)
Focal Epithelial Hyperplasia , Nigeria , Salicylic Acid , ZincABSTRACT
Objective: Multifocal epithelial hyperplasia (MEH) or Heck's disease is an uncommon oral mucosa disease caused by the Human Papilloma Virus (HPV) especially subtypes 13 or 32. It is contagious with a tendency to be transmitted to other family mem bers. There is geographic hic regional variation in the frequency of occurrence of this condition. A careful clinical examination is required to arrive at the diagnosis. Histopathological review however can help to confirm the diagnosis of MEH. Molecular biology techniques like PCR or ISH are useful in isolating the HPV subtypes involved. This report aims to highlight the clinical features of MEH for accurate clinical diagnosis by Dental and Medical Practitioners Case Report: A documentation of a case of a 6-year-old Efik, Nigerian male child with extensive multiple oral mucosa lesion of 2 years' duration. The diagnosis of this case was based on the clinical presentation. The presence of multiple painless pink to whitish oral mucosa papules and nodules on the lips, labial and buccal mucosa was seen and a diagnosis of Multifocal Epithelial Hyperplasia was made. Conclusion: We report a case of MEH, a rare benign oral mucosal lesion in a 6 -year-old male of the Efik ethnic group in the south-south zone of Nigeria who presented with a 2year history of multiple lesions in the oral mucosa. It is important for Dental and Medical practitioners to be aware of this rare condition