ABSTRACT
Infection with Helicobacter pylori is a worldwide problem. It plays an important role in gastric malignancies.The pathogenesis of gastric malignancies involves multistep progression changes in gastric mucosa and the Helicobacter pylori infections is the first step in most of cases.Aim:The aims of this study were to clarify the benign changes in gastric mucosa after Helicobacter pylori infection;to evaluate the endoscopic and histological patterns of infection and to correlate endoscopic findingwith histopathological parameters.Materials and Methods:A descriptive, retrospective study was done in Soba University Hospital between January 2009 - February2013. Paraffin-embedded blocks, Giemsa and Haematoxylin and Eosin-stained slides, were obtained from 50 cases of Helicobacter pylori-associated chronic gastritis and examined under light microscopy. The clinical information and endoscopy findings were obtained from the records. The data was analyzed using Statistical Package for Social Sciences Software.Results:The most common affected age group was between 40-60 years. The prevalence of infection was equal in males and females. The commonest endoscopic finding was inflammation of gastric mucosa. Most patients presented with moderate degree of colonization; 62% of patients presented with a severe degree of chronic inflammation. There was a significant statistical correlation between the degree of Helicobacter pylori colonization and the degree of chronic inflammation (p<0.05). Most patients presented with severe degree of active gastritis. A significant correlation was found between the degree of chronic inflammation and degree of activity. The prevalence of lymphoid follicles in a single biopsy specimen from antral mucosa was 36%.The dysplasia was seen in 12%; eosinophilia 8%; atrophy 8% and intestinal metaplasia in 6% of the cases.No significant correlation was found between the endoscopic findings and histological findings.Conclusion:Helicobacter pylori infection causes chronic active gastritis and it has a role in the development of lymphoid follicles, intestinal metaplasia, atrophy and dysplasia
Subject(s)
Gastric Mucosa , Helicobacter pylori , Stomach Ulcer , SudanABSTRACT
Background and study aim: This study proposed to assess the relation between absolute telomere lengths (TLs) in gastric mucosa and Helicobacter pylori (H. pylori) infection and study the impact of (H. pylori) eradication therapy on TLs. Patients and Methods: This study was conducted on (42) subjects divided into two groups, group I: included (17) H. pylori negative cases served as control group, group II: included (25) H. pylori positive patients. Absolute TLs was measured in base pairs (bp) in gastric mucosa and analyzed by real time polymerase chain reaction (RT-PCR) in all groups and reevaluated in H. pylori positive patients 4 weeks after eradication therapy. Results: Prior to eradication therapy, there was highly significant shortening (P<0.001) in TLs (bp) in gastric mucosa of H. pylori positive patients compared to H. pylori negative controls. While there was highly significant elongation was observed after H. pylori eradication therapy in H. pylori positive patients (P < 0.001). There was significant negative correlation between TLs and ages of patients (P<0.001) while there was no significant relation between TLs and sex (P= 0.5) before and after eradication therapy. Conclusion: H. pylori positive patients had significantly shorter TLs than H. pylori negative controls. TLs were increased after H. pylori eradication therapy in H. pylori positive cases. This finding may indicate the importance of H. pylori eradication to avoid the development of gastric cancer by its effect on TLs