Aggressive central giant cell granuloma of the mandible: A case report and review of literature

Mandibular aggressive central giant cell granuloma is a rare non-neoplastic giant cell tumour characterised by pain, bone destruction, tooth root resorption, jawbone cortical perforation, and high recurrence rate. This is a case of a 10-year-old boy who presented to the Dental Surgical outpatient clinic of University of Uyo Teaching Hospital with a three-year history of left jaw swelling. The clinical diagnosis was fibrous dysplasia of the left hemi-mandible. Consequently, left hemi-mandibulectomy was performed, and subsequent histopathological diagnosis was aggressive central giant cell granuloma of the mandible. This article presents this rare diagnosis and explores its classification, aetiopathogenesis, clinico-pathological features and management.

Inflammatory and reactive lesions of the orofacial region in an African tertiary health setting

Background: Chronic inflammatory and reactive lesions are tumor­like hyperplasia that are produced in association with chronic local irritation or trauma. These proliferations are painless pedunculated or sessile masses in different colors, from light pink to red. The surface appearance is variable from nonulcerated smooth to ulcerated growth, and they from a few millimeters to several centimeters in size. Common examples in the oral cavity include pyogenic granuloma (PG), epulis, traditional clinical name for gingival reactive proliferations, Irritation fibroma, epulis fissuratum, and giant cell granulomas which could either be of peripheral or central origin.Objective: To describe the pattern of inflammatory and reactive lesions of orofacial region. Materials and Methods: A retrospective study of patients attending the oral and maxillofacial clinic between January 2006 and December 2014 was undertaken. Results: One hundred and twelve patients, comprising 61 (54.5%) males and 51 (45.5%) females were seen over the period of study. Their age ranged from 1 to 80 years with a median age of 26.5 years. PG was the most frequently reported lesion accounting for 32 (28.6%). This was followed by nonspecific chronic inflammation (n = 23; 20.5%), epulis/peripheral giant cell granuloma (n = 13; 11.6%), granulation tissue (n = 10; 8.9%), and central giant cell granuloma, (n = 8; 7.1%). Conclusion: The results of the study show that inflammatory and reactive lesions are common in the study population