Profil hématologique des patients atteints de COVID-19 au niveau du CHU d'Oran en Algérie / Hematological profile of patients with COVID-19 at Oran University Hospital in Algeria

Introduction: La COVID-19 est une zoonose virale causée par la souche de coronavirus SARS-CoV-2. Vue la rapidité de sa propagation, l'OMS a qualifié cette maladie infectieuse émergente de pandémie internationale. L'objectif de notre étude est de décrire les caractéristiques hématologiques des patients atteints de COVID-19 hospitalisés au niveau du CHU d'Oran en Algérie. Patients et méthodes : Il s'agit d'une étude prospective menée entre le 1er Juillet et le 15 Octobre 2020 ayant inclus des patients hospitalisés et/ou suivis au niveau des unités COVID-19 du CHU Oran en Algérie. La numération de formule sanguine a été faite sur un automate Mindray BC ­ 6800. Résultats : Notre étude a inclus 68 patients dont 67,2% de sexe masculin et 32,8% de sexe féminin (sexe ratio H/F = 2) avec une médiane d'âge de 65 ans. Les bilans ont révélé une anémie chez 38,2 % des patients. Une hyperleucocytose (62,2%), une hyperneutrophilie (72,1%), une lymphopénie (66,2%) ,Une éosinopénie (58,8%), une monocytopénie (08,8%), une monocytose (20,6%), une thrombopénie (20,6%), une thrombocytose (14,7%), un VPM (Volume Plaquettaire Moyen) élevé dans 27,9% des cas et un IDP (Indice de Distribution Plaquettaire) élevé chez tous les patients. On constate aussi que 85% des patients âgés de plus de 50 ans ont un NLR ≥ 3,13. Conclusion : Certains paramètres tels que la lymphopénie et l'éosinopénie présentent une valeur diagnostique importante, alors que d'autres paramètres tels que le NLR (Neutrophils-to-lymphocytes ratio), le MLR (Monocyte -to-lymphocytes ratio) et le PLR (Platelet-to-lymphocytes ratio) offrent une valeur pronostique très précieuse.

Haematological values in a healthy adult population in Yaoundé, Cameroon

Background: Haematological values derived from local populations are useful in laboratories to improve diagnoses for local patients. In Cameroon, these data are not yet available. Moreover, there is great variation in baseline parameters pertaining to full blood cell count among medical laboratories.Objectives: This study aimed to determine values for the complete blood cell count of a healthy adult Cameroonian population for use in locally derived ranges in our medical laboratories.Methods: A cross-sectional study was conducted among blood donors attending three blood banks in Yaoundé from November 2015 to September 2016. We expected to obtain at least 120 venous blood samples from both men and women. Tests were performed for (1) HIV, (2) complete blood cell count, (3) hepatitis B virus, (4) malaria, (5) syphilis, (6) C-reactive protein and (7) hepatitis C virus.Results: We enrolled 294 healthy participants (161 men, 133 women) aged 18 to 55 years. The median haemoglobin concentration was 135 g/L in men and 114 g/L in women (p < 0.001). The median reticulocyte count was 60 × 109/L in men and 40 × 109/L in women (p < 0.001).Significant variation by sex was observed for the platelet count. The median white blood cell count was 4.1 × 109/L in men and 4.6 × 109/L in women (p = 0.008). Conclusion: This study provides locally derived ranges for complete blood cell and reticulocyte counts for a healthy adult population in Yaoundé, Cameroon. These results can be used pending larger studies

Investigating the importance of haemoglobin measurement for selection of blood donors in Libya

In Libya, haemoglobin estimation is not used routinely to assess the fitness of blood donors. We examined the importance of including this parameter in donor selection. Venous blood samples were collected from the bleed line at the end of the donation process from 1339 healthy adult male blood donors, aged 18­60 years, in Al-Jala Women Hospital in Tripoli, Libya. Haemoglobin concentration was measured using an automated haematology analyzer. The main donor age categories were 21-30 and 31-40 years (49.5% and 37%, respectively). Blood donation was mainly a replacement donation. The mean ±2SD range for haemoglobin was 10.8­17.0 g/dl. 27.2% of the donors had haemoglobin concentration of less than 13 g/dl, 16.9% of them had less than 12.5 g/dl and 1.9% had less than 10.8.5 g/dl.Our results suggest that it is important to include haemoglobin estimation as a routine procedure in selection of blood donors

Pre-operative haematological investigation in paediatric patients for elective surgery

Haematological investigations for 225 paediatric patients aged between zero to 15 years who presented for elective surgery were studied retrospectively over a five-month period. In addition to the Haemoglobin (Hb); the Sickling test and the haemoglobin electrophoresis where applicable were done. Thirty per cent (30 per cent) of the patients had Hb of 10g/dl and below. The lower Hb was found more commonly in the age group zero to 5 years. Eleven (4.9 per cent) patients did not have the Sickling test done. Twenty-three (23) out of 29 patients with Sickling positive had electrophoresis done. The results were 21 AS; 1 SS; and 1 SC. Blood film for malaria parasites yielded positive results in 33 out of 175 (18.9 per cent) patients. There were no immediate anaesthetic complications in any of the patients. The need for minimum test of Hb; Sickling and blood film for malaria parasites are discussed

Haematological indices of Nigerians with sickle cell anaemia

Sickle cell anaemia patients in steady state have haematological values different from the normal population. Sickle cell patients are in a steady state when they are not in crisis and have no bacterial infection. The haemoglobin level is low and reticulocyte count high. There is also peripheral leucotosis and thrombocytosis

Haematological indices and serum lead level in welders working in automobile industry in a Nigerian city

Forty-four welders working in car maintenance industry in Jos; Nigeria had their haemoglobin; haematocrit; leucocyte; platelet and serum lead level determined; while their urine were screened for haem synthetic products. The serum lead level in welders was 28.5 plus 11.2/ng/dl which was significantly higher than the value of 20.8 plus 9/ng/dl recorded for the control group. Though 24 welders who had worked over 10 years had higher serum levels than 20 welders who had worked for less than 10 years this was not statistically significant; also urine examination did not reveal the presence of porphyrinogen or porphyrin in the welders