COVID-19 related multisystem inflammatory syndrome in children (MIS-C): A case series from Ethiopia

Background: One in hventy ofpeople qffected by the ongoing COVID-19 pandemic have been children and adolescents. A unique complication in this age group is the Multi-inflammatory syndrome associated Il'ith COVID-19 (MS-C). We report a single-center case series ofchildren diagnosed with MS-Cfrom Addis Ababa, Ethiopia. Case descriptions This case series describes the clinical presentation and treatment outcomes offour male patients presenting at a mean age of3 years and 11 months. Allfulfilled the World Health Organization case definition criteria for the Multi-inflammatomy syndrome associated 'Vith COVID-19. All "'ere not eligible for vaccinations against severe acute respiratory syndrome coronavirus 2 (SARS CoV-2) at the time oftheir diagnosis. They were treated with varying combinations of intravenous immunoglobulin, aspirin, and corticosteroids, and all recovered upon completion oftheirfollow-up period. Conclusion: Cases of Multi-inflammatomy syndrome associated with COVID-19 are often misdiagnosed. This case series highlights when to consider such a diagnosis and its therapeutic options

Convalescent plasma or hyperimmune immunoglobulin for people with COVID­19

Convalescent plasma is being considered as a potential therapy for COVID­19. We highlight and contextualise the findings of a recent Cochrane rapid review that evaluated the effectiveness and safety of convalescent plasma or hyperimmune immunoglobulin transfusion in the treatment of people with COVID­19. The review found low­certainty evidence of the therapeutic effectiveness and safety of convalescent plasma. As the novel coronavirus continues to spread in South Africa (SA), convalescent plasma may offer a therapeutic ray of hope for mitigating the morbidity and mortality burdens of the disease. Further investigation of the clinical benefits of the therapy in well-designed studies is needed to provide more evidence that will guide COVID-19 treatment decision-making in the SA context

Prevalence of chlamydia trachomatis infection in infertile women attending fertility clinics in Benin city, Nigeria: a public health concern

This study was carried out to deduce the prevalence of Chlamydia infection amongst infertile women attending fertility clinics in Benin City, Nigeria. Fifty infertile women with either primary or secondary infertility and with their ages ranging from 24 to 51 years were enrolled for this study. The serum of each patient was screened for Chlamydia antibodies with the enzyme-linked immune-sorbent assay (ELISA) and immunoglobulin G (IgG) index of 0.90 or less was reported as seronegative for IgG antibody, while IgG index of 1.00 or greater were positive for IgG antibody. Findings in the present study revealed that 24 % to 52 % of the patients that attend the fertility clinics in Benin City, Nigeria were most likely to be infected with Chlamydia; with the primary infertile patients accounting for 32 % of the cases and secondary infertile patients for 68 % of the cases. Prevalence of Chlamydia infection was also found to be quite high amongst women aged between 36 and 40 years old. Since lack of symptoms often makes the clinical diagnosis of Chlamydia infection somewhat difficult, thus increasing the prevalence of this disease; routine screening is recommended to enable early therapeutic interventions of positive cases

Plasma Interferon-gamma and IL-4; Immunoglobulin Classes and Nitric Oxide in Nigerians with Acute Leukaemia

Acute leukaemia are usually rapidly progressive with death often occurring in a few weeks to a few months in untreated patients as a result of abnormal hematopoietic function as well as impaired immune response. The risk of relapse which remains in 20 of patients in remission calls for more research on acute leukaemia. This study therefore; evaluated the plasma levels of nitric oxide (NO); interleukin-4 (IL-4); interferon-gamma (IFN-?) and immunoglobulin classes (IgA; IgG; IgM; IgE) in twenty-five (25) patients with acute leukaemia (AL) and twenty-five (25) apparently healthy controls. The mean levels of plasma IgA; IgG and IgM were not significantly elevated in leukaemia patients compared with control. However; the mean plasma levels of IgE; NO; IL-4 and IFN-? were significantly elevated in leukaemia patients compared with controls. It could therefore be concluded from this study that humoural immunity is not depressed in acute leukaemia patients

Purification des immunoglobulines A, G et M : préparation d'immunoserums a visée diagnostic

L'objectif du present travail est de presenter une technique rapide de preparation des immunoglobulines A; G et M avec un rendement suffisant et une purete immunoelectrophoretique a 100 pour cent pour etre utilises pour immuniser des chevres aux fins de production d'immunoserums