Donor related risk factors on the outcome of living donor liver transplantation

Background & objective: Liver transplantation is an established, effective treatment for acute and chronic end stage liver disease. Donors risk factors should be studied in order not to compromise the procedure of transplantation or to lose candidates for transplantation, the study aims to evaluate the effect of variable donor risk factors on the outcome of Living donor liver Transplantation regarding the morbidity and mortaly .Methods: the current study conducted on 48 patients who underwent living donor liver transplantation for End stage liver disease caused by chronic HCV. Morbidity and mortality were assessed at three and twelve months. Obtained data were studied in correlation with various donor related risk factors, a score designed to collect these risk factors, correlate them with recipient mortality, and graft rejection.Results: high rates of graft rejection and recipient mortality was significantly related to older donor age, donor obesity, donorrecipient gender mismatch, hepatic steatosis, and donor graft recipient weight ratio (GRWR) ≤ 0.8. The designed donor risk score of ≥ 7 was expectedly to associate with poor outcome & recipient mortality.Conclusion: The present study suggested that donor risk score can be a strong predictor of donor related risk factors and its effect on the outcome of Living Donor Liver Transplantation in patients espicially with hepatitis C genotype 4

Restoration of liver mass after partial hepatectomy - implications for living donor liver transplantation : transplantation

In living donor liver transplantation; the recipient liver undergoes more rapid regeneration than the remnant liver in the donor. In this study we investigated the factors which may be responsible for the difference in the regenerative response between the donor and the recipient. Long Evans rats were subjected to either partial hepatectomy (PH) or sham operation (SH) and were treated with liver cytosol (C) and cyclosporine (Cy). The rats were sacrificed at 24; 48; 72 and 96 hours and 1 and 2 weeks postoperatively. The livers were removed to determine the liver weight/body weight (LW / BW ) ratio and the mitotic index. The mitotic index; serum aspartate transferase (AST) and serum alanine transferase (ALT); although unchanged in the SH groups; were increased in the rats treated with PH + C + Cy; and were greater than after PH only. However LW / BW ratios increased after PH but had returned to preoperative levels by 2 weeks. The changes in LW / BW ratio were not modified by the cytosol or cyclosporine