ABSTRACT
Introduction. L'efficacité du traitement antirétroviral dans la restauration immunitaire dépend fortement du stade de l'infection et du taux de lymphocyte TCD4 au moment de l'introduction du traitement. Nous avons évalué le taux de lymphocytes TCD4 à la découverte de la séropositivité au VIH pour caractériser le niveau d'infection de chaque patient. Matériel et méthodes. C'est une étude transversale et descriptive qui s'est déroulée dans le laboratoire de virologie de la faculté de médecine de Libreville. Nous avons analysé les données de la cohorte DERIRADO. Résultats. Nous avons inclus 133 patients. L'âge médian était de 45 ans (Q1-Q3 :ï37 ; 52ï). La médiane de LTCD4 était de 388 cellules/mm3 (Q1-Q3 : ï250 ; 556ï). Le diagnostic était avancé chez 112 (84%) patients. Conclusion. La découverte de la séropositivité au Virus de l'Immunodéficience Humaine est faite à un stade d'immunodépression avancé chez la majorité des patients. Ce constat relève la nécessité de mettre en route les politiques de sensibilisation pour cibler les populations clés et amener le plus grand nombre au dépistage de l'infection par le Virus de l'Immunodéficience Humaine si l'on veut diminuer la courbe de transmission.
Introduction. The effectiveness of antiretroviral therapy in immune restoration largely depends on the stage of infection and the TCD4 lymphocyte count at the time of treatment initiation. We evaluated the rate of TCD4 lymphocytes at the discovery of HIV seropositivity to characterize the level of infection of each patient. Methods. This was a cross sectional descriptive and analytic study whose setting was the laboratory of virology of the faculty of medicine of Libreville. Our data source was DERIRADO cohort. Results. We included 133 patients. The median age was 45 (Q1- Q3:37;52). The median LTCD4 was 388 cells/mm3 (Q1-Q3: 250; 556). The diagnosis was advanced in 112 (84%) patients. Conclusion. The diagnosis of seropositivity to the Human Immunodeficiency Virus is made at a stage of immunosuppression in the majority of patients. This highlights the need to implement sensitization policies to target key populations and bring as many people as possible to screening in order to reduce the transmission curve
Subject(s)
HIV Seropositivity , Treatment Outcome , CD4 Lymphocyte Count , Anti-Retroviral Agents , Lymphocytes , DiagnosisABSTRACT
Objective: We investigated whether psychopathology in HIV-positive patients was associated with more negative fundamental assumptions than in healthy controls. In addition; we explored whether psychopathology and negative fundamental assumptions in HIV-positive patients were associated with lower CD4 T-lymphocyte counts. Method: Self-rating questionnaires to assess depressive symptoms; posttraumatic stress symptoms; alcohol abuse; general psychopathology and fundamental assumptions; were completed by 123 HIV-positive patients and 84 uninfected clinic attendees at three primary health care clinics in the Western Cape; South Africa. CD4 T-lymphocyte counts were obtained from chart records. Results: HIV-positive patients reported more depressive and posttraumatic symptoms than uninfected individuals. However when controlling for socio-economic status; the number of traumatic events experienced and other potential confounds; no differences remained. Fundamental assumptions (FA) were mainly positive in both HIV-positive patients and controls and no correlations were found between fundamental assumptions; psychiatric symptoms and CD4 levels. However; in infected patients FA and psychopathology were negatively associated with all participants scoring in the positive range of the FA scale. Conclusion: The positive scores on the FA scale indicate that positive assumptions are related to less psychopathology. Longitudinal studies investigating the association between the valence of fundamental assumptions and HIV morbidity are needed
Subject(s)
HIV Seropositivity , Lymphocytes , Patients , Psychopathology , Signs and SymptomsABSTRACT
L'etude retrospective du profil clinique et biologique de la leucemie lymphoide chronique portant sur 50 cas recrutes dans les services d'hematologie clinique du CHU de Yopougon et de Option : Medecine interne du CHU de Treichville a permis de retenir les resultats suivants. Au plan clinique et epidemiologique : il existe une legere predominance feminine avec un sex-ratio de 0;43; l'age moyen est de 60;46 ans; la tranche d'age predominante est celle de 61 a 70 ans; le groupe ethnique le plus atteint est le groupe KWA; 72 pour cent; les menageres sont les plus exposees. 60 pour cent; le syndrome tumoral domine le tableau clinique avec; au premier rang la splenomegalie dans 32 pour cent. Au plan biologique : il existe une hyperleucocytose moderee et constante dans 78 pour cent des cas; la lymphocytose medullaire est constante chez 70 pour cent de nos patents; la lymphocytose sanguine est moderee (inferieure a 50000 mm3) chez 86 pour cent de nos patients; leucemie lymphoide chronique; syndrome tumoral ; lymphocytose sanguine et medullaire; lymphocytes
Subject(s)
Leukemia, Lymphocytic, Chronic, B-Cell/epidemiology , LymphocytesABSTRACT
The paper explains the pharmacological effects of the drug which include vacuolation and degeneration of the worm. The degeneration of parasite surface as well as migration into the worm is a critical event in the action of PZQ