ABSTRACT
Background: Environmental exposure to toxins has been strongly implicated in its multi-faceted etiology of chronic kidney disease, a serious public health problem affecting individuals, families, and communities. There is a need to synthesize available studies on the effect of heavy metal exposure on renal function, considering the rising global burden of kidney disease. The objective of this study is to determine the association between exposure to heavy metals and renal disease. Methods: The Preferred Reporting Items for Systematic Review and Meta-Analysis (PRISMA) were used to conduct the review. A comprehensive independent search, title, abstract, and full-text screening of available literature on Google Scholar, PubMed, and OAREScience was done between March 2021 and May 2021. The criteria for study inclusion were full-text articles published in English language in the last 20 years (2001-2020), and observational primary human studies reporting the association between heavy metal exposure and renal disease. The Newcastle-Ottawa Quality Assessment Scale was used to assess the quality of the included studies. Results: A total of 552 studies were identified following the search from the different databases. A total of 13 studies were finally included in the review. Heavy metals implicated in the studies include cadmium, lead, mercury, and arsenic, with ten studies showing environmental exposure as the primary source. Ten (10) studies showed an association between heavy metal exposure and renal impairment (p<0.05) while only 3 studies reported no association. Conclusion: Environmental monitoring is needed to stem the tide of heavy metal exposure in view of the growing burden of chronic kidney disease.
Subject(s)
Humans , Male , Female , Metals, Heavy , Environmental Exposure , Renal Insufficiency, Chronic , Systematic ReviewABSTRACT
Introduction : Lubumbashi, première ville du Katanga et deuxième grande ville de la République Démocratique du Congo, est une zone minière et le poumon économique du pays. De ce fait, elle constitue le siège d'une effervescence d'activités minières artisanales et industrielles. Ce travail vise à évaluer la bioaccumulation ou l'intoxication des métaux lourds dans la population des enfants malnutris. Matériel et méthodes : Le cobalt, le chrome, l'antimoine et le Plomb ont été dosés dans le sérum chez les enfants de moins de 5ans (n = 311). L'ICP OES ou le spectrophotomètre d'absorption atomique couplé à un spectrophotomètre à émission optique ont été utilisés pour le dosage. Trois cent onze enfants ont été colligés au cours de la période allant du 1 Juillet 2013 au 31 décembre 2014. Les analyses statistiques ont été réalisées au moyen du logiciel Epi Info 7.1.1.0. Résultats : Parmi les métaux lourds, l'antimoine s'est révélé moins toxique que les autres, tandis que les prévalences et risques de pollution significatifs suivants ont été observés chez les enfants malnutris : 76 % (OR [IC 95 %] : 1,5[1,04-2,25]) pour le chrome, 58 % (OR [IC 95 %] : 1,7[1,18-2,59]) pour le cobalt et 58 % pour le Plomb (OR [IC 95 %] : 1,7[1,15-2,65]). Conclusion : L'intoxication aux métaux lourds reste un problème de santé à Lubumbashi dans la population en général, particulièrement chez les malnutris. Plus l'enfant est jeune, de sexe féminin plus, il était exposé à l'intoxication aux métaux lourds plus polluants dans la majorité des cas. Pour la plupart les zscores PPA et TPA étaient au-delà de 2 avec une différence statistique hautement significative.
Subject(s)
Child Nutrition Disorders , Metals, Heavy , Malnutrition , Heavy Metal Poisoning , Poisoning , Nutritional StatusABSTRACT
ABSTRACT: The health hazards posed by heavy metals in water and the need to mitigate the hazards have attracted a flurry of research interests on the technologies and methods of removing them from water. The industrial waste water from a gutter within the neighbourhood of the Delta Shopping Mall in Effurun was used to test the heavy metal sorption capacity of the waste high density polythene and biowaste composites compounded by the author using a locally constructed extruder. Some of the physico chemical properties of the waste water determined with PH Kent meter (model 7020) and Hach conductivity meter (C0150) where within WHO acceptable limits while some were not. The metal concentrations were determined using Atomic Absorption Spectrometer(Perkin Elmer Absorption Analyst 400 model) The Composite of 2:1.5:0.5 (HDPE: saw dust: egg shell) sorbed the highest concentration of the metals ( 0.168mg/L, Fe; 0.072mg/L, Ni and 0.082mg/L, Cr than the other composites of 1.5: 1: 1.5 and 2:1:1 except Cd while the composite, 2:1:1 sorbed the least concentration of metals( 0.061mg/L, Fe; 0.044mg/L, Ni; 0.071mg/L, Cr and 0.002mg/L, Cd during the first 24 hours of sorption exposure. Chromium was the most sorbed metal, 97.6% while cadmium was the least, 20.0%. There was no systematic pattern of variation for metal absorption in the next 24 hours due probably to the blocking of the pore sites during the first twenty four hours of sorption exposure. The composite, 2:1.5:0.5 exhibited a good potential as an economic heavy metal sorbent
Subject(s)
Metals, Heavy , Nigeria , WastewaterABSTRACT
ABSTRACT: This study determined the levels of some heavy metals at resident and remediated soils of uncontrolled gold mining activities with a view to providing information on the extent of contamination and ecological risk to the resident area. The soil samples were collected from two site at the resident and one remediated soil, and analyzed for metals (Cr, Ni, Pb, Fe, Cu, Cd and Mn) using Atomic Absorption spectrophotometer (AAS). The concentrations of heavy metals (mg/kg) in residents samples ranged from 1.500-13.30 (Cr), 0.0001-0.05 (Ni), 0.18- 3.754 (Pb), 0.0003-0.10 (Fe), 0.0005-0.88 (Cu), 0.0009-0.27 (Cd) and 0.0003-0.0035 (Mn) and for the remediated sample are 12.3000, 0.0001, 1.1989, 0.0002, 0.0006, 0.0003, and 0.0003 for Cr, Ni, Pb, Fe, Cu, Cd and Mn respectively. The calculated geo-accumulation index (Igeo) shows that the soil samples fall under unpolluted to moderately pollute for all the studied metals with respect to all studied sites. Pollution Load Index values (PLI>1) were all less than 1 for each metals in all studied sites, thus indicating perfection. The contamination factor (Cf) and degrees of contamination (Cd) of the soil samples were very slightly contaminated to slightly contaminated with Cr and Cd; The ecological risk results revealed that site A, B and Remediated samples were fall under low ecological risk index with values of 0.28, 10.28 and 0.33 respectively. The contaminations of these studied metals may not add ecological risk to the local environment