ABSTRACT
Background. Multiple sclerosis (MS) is a disease that predominantly affects the young female population. It is important for an obstetrician to know the effects of pregnancy on MS, and vice versa. Objective. To demonstrate the impact of MS on pregnancy outcomes. Methods. We retrospectively evaluated demographic features, clinical characteristics, and obstetric outcomes of 47 pregnancies in 24 patients with MS, between January 2007 and December 2016. Results. Patients were divided into three groups: (i) 35 pregnancies in patients with MS who were in remission at the beginning of pregnancy; (ii) 10 pregnancies in patients with MS whose disease was exacerbated at the beginning of pregnancy; and (iii) 2 pregnancies in patients with active MS whose symptoms were relieved after becoming pregnant. The overall early pregnancy loss rate was 36.2%, whereas it was 60% and 31.4% in the exacerbation and remission groups, respectively; and the overall preterm delivery rate was 30%, while it was 29.1% and 50% in the remission and exacerbation groups, respectively. Conclusion. Miscarriage and preterm delivery seem to be significant obstetric complications in pregnant women with MS
Subject(s)
Multiple Sclerosis , PregnancyABSTRACT
Introduction. Caracterisee par une demyelinisation de la substance blanche du systeme nerveux central; la Sclerose en plaques (SEP) se manifeste cliniquement par des tableaux encephaliques et/ ou medullaires subaigus. Il existerait un gradient Nord-Sud dans la repartition de la maladie. Les populations africaines (noires en particulier) et orientales seraient moins atteintes. La Mauritanie; par la diversite ethnique de sa population et sa situation geographique (trait d'union entre ces 2 regions) peut constituer un terrain interessant pour l'etude de cette maladie. De plus l'introduction de l'IRM dans notre pratique medicale depuis juillet 2005; constitue un atout pour le diagnostic de cette affection.Objectif. Presenter des observations de patients mauritaniens dont les tableaux cliniques et les explorations etaient en faveur d'une SEP. Methode. Nous avons selectionne 4 observations de malades hospitalises dans le Service de Neurologie du Centre Neuropsychiatrique de Nouakchott en Mauritanie; en 2005. Apres un examen clinique neurologique; ils avaient beneficie d'une exploration par IRM. Resultats. Le plus jeune de notre serie a 17 ans et le plus age 55 ans. Tous les patients etaient d'ethnie maure; trois etaient de race noire et un etait de race blanche. Tous ont presente des signes fortement evocateurs de SEP. Nous avons observe une forme d'emblee progressive; deux formes remittentes; et une premiere poussee chez une jeune fille. Les resultats de l'IRM cerebrale chez les 4 patients et de l'IRM medullaire chez trois patients ont montre des plaques de demyelinisation. Un seul patient pu avoir l'electrophorese des proteines du LCR qui a permis de montrer une distribution oligoclonale
Subject(s)
Demyelinating Diseases , Mauritania , Multiple Sclerosis/diagnosisABSTRACT
Background : Locked-in syndrome is an extremely difficult neurologic condition to recognize; especially by the non-specialists. A case of locked-in syndrome in a 41-year old Niger Deltan Nigerian with relapsing remitting form of multiple sclerosis (MS) is presented; including a detailed literature review. Patient and Case Report The patient was in a state of spastic quadriplegia; motionless and aphasic (mute); with the preservation of consciousness and the ability to open and blink the eyes and move them vertically. Two episodes of the disease; varying in duration; have been described. The diagnosis of MS was made from the history and the typical clinical presentation: history of relapsing and remitting signs and clinical evidence of multi-focal involvement of the central nervous system. Conclusion Patient died at the age of 45 years; from pulmonary complications. This article may enhance easy recognition and management of the syndrome by all clinicians
Subject(s)
Multiple Sclerosis/diagnosis , Prognosis , Quadriplegia , ReviewABSTRACT
Background : Locked-in syndrome is an extremely difficult neurologic condition to recognize; especially by the non-specialists. A case of locked-in syndrome in a 41-year old Niger Deltan Nigerian with relapsing remitting form of multiple sclerosis (MS) is presented; including a detailed literature review. Patient and Case Report The patient was in a state of spastic quadriplegia; motionless and aphasic (mute); with the preservation of consciousness and the ability to open and blink the eyes and move them vertically. Two episodes of the disease; varying in duration; have been described. The diagnosis of MS was made from the history and the typical clinical presentation: history of relapsing and remitting signs and clinical evidence of multi-focal involvement of the central nervous system. Conclusion Patient died at the age of 45 years; from pulmonary complications. This article may enhance easy recognition and management of the syndrome by all clinicians
Subject(s)
Multiple Sclerosis/diagnosis , Prognosis , Quadriplegia , ReviewABSTRACT
Spinal and scalp somatosensory evoked potentials obtained by tibial nerve stimulation were recorded in 24 normal adult Nigerians and 11 patients with non-traumatic spinal cord disorders. The morphology and means of latencies of the major somatosensory evoked potential (SEP) components in the normal subjects (N21: 22.6 + 1.4 msec; P40: 39.1 + 2.5 msec; N50: 48.3 + 2.3 msec and P60: 62.4 + 3.9 msec) were similar to those reported in other populations. Seven of the 11 patients had abnormal central somatosensory conduction (CSC) as judged by a weighted scoring scheme. This was abnormal in all four patients with impaired proprioception and in three of seven patients with normal proprioception. This preliminary report shows that SEP studies are useful in detecting sub-clinical posterior column dysfunction in Nigerian patients with spinal cord disorders and the severity of this could be graded with the CSC scoring scheme