Efficacy of garcinia Kola 0.5 aqueous eye drops in patients with primary open-angle glaucoma or ocular hypertension

PURPOSE:To evaluate the intraocular pressure (IOP) lowering efficacy of Garcinia kola 0.5% aqueous solution eye drops in patients with newly diagnosed primary open-angle glaucoma or ocular hypertension (POAG/OH).MATERIALS AND METHODS: A randomized, double-masked, multicenter, active-controlled prospective study. Patients who met the inclusion criteria were randomly assigned in equal numbers to receive Timolol 0.5% eye drops as a control medication (A = Group 1 eyes) or Garcinia kola 0.5% eye drops as the study medication (B = Group 2 eyes). All drops were instilled at 6 am and 6 pm daily. Goldman applanation tonometry was performed at 9 am, 12 pm and 3 pm at baseline, week-6, week-12 and week-24 visits. Voluntary and actively elicited reports of adverse events were documented. The mean change in IOP over 24 weeks was the primary outcome measure. Both groups were compared for statistically significant differences at all visits. A P < 0.05 was considered statistically significant.RESULTS:A total of 178 patients were randomly assigned to G. kola and Timolol groups. At baseline there were no differences in mean IOP between groups, based on age, sex, or diagnosis. At the end of the study period (24(th) week), the mean (+/- SD) reduction in IOP was 12.93 +/- 2.3 mmHg (47.8% +/- 0.8% reduction) in G. Kola group and 13.09 +/- 2.8 mm Hg (48.2% +/- 1.03% reduction) in the Timolol group (P > 0.05). Adverse events were mild in nature with no statistically significant differences between groups (P > 0.05).CONCLUSIONS:Garcinia kola ophthalmic solution significantly reduces IOP as compared to baseline. The IOP lowering effect of both treatments was equivalent

Mieux prescrire le timolol dans hypertension intraoculaire et dans le glaucome chronique a angle ouvert

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Contribution a l'etude clinique et evolutive des manifestations ophtalmologiques du lymphome de Brukitt. Etude de 50 cas colliges dans les de Yopougon et de Treichville

Notre etude est a la fois retrospective et prospective. Elle nous a permis d'apprecier les manifestations ophtalmologiques du lymphome de Burkitt sur 50 cas colliges dans les CHU de Yopougon et de Treichvillede 1990 a 2000.Au terme de ce travail; il ressort que:* la frequence des atteintes ophtalmologiques est de 18pour cent.* Ces atteintes se rencontrent dans 46pour cent des cas au cours des localisations maxillo-faciales du lymphome.Dans 50pour cent des atteintes; le lymphome est de stade III.* Les troubles visuels representent le premier motif de consultation.* L'exophtalmie et l'hypertension intraoculaire representent respectivement 54pour cent et 40pour cent des manifestations.* Les complications oculaires representent 40pour cent et celles relatives aux annexes 36pour cent.* Dans 46pour cent des cas; les complications evoluent defavorablement