Subject(s)
Fertility , Fertilization in Vitro , Hormones , Ovulation Induction , Reproductive Health ServicesABSTRACT
Introduction. Polycystic ovarian disease (PCOS) can account for up to 35 - 40 of the female factor causes of infertility. These patients present as medically complex cases and are challenging to manage and treat successfully. They are resistant to treatment and are often offered controlled ovarian stimulation (COS) and in vitro fertilisation (IVF) technology. Aim. The aim of this study was to assess whether there was a difference in the pregnancy outcomes of women with PCOS when a standard gonadotrophin-releasing hormone (GnRH) antagonist (cetrorelix) protocol was used for ovarian stimulation; compared with non-PCOS patients undergoing IVF. Methods. A retrospective patient record audit was performed on 142 patients with PCOS and 501 non-PCOS patients undergoing a similar cetrorelix-based COS treatment protocol during a specified time period. Results. The main primary outcome was an ongoing pregnancy at 12 weeks; achieved in 34 of patients in the PCOS group and 27 in the non-PCOS group. This was not significantly different (p=0.07). No patient in the PCOS group experienced severe hyperstimulation syndrome. Conclusion. There was no significant difference in pregnancy rates in patients with PCOS undergoing GnRH-antagonist ovarian stimulation compared with non-PCOS patients. The fact that no hyperstimulation syndrome occurred makes this an attractive option for women with PCOS
Subject(s)
Gonadotropin-Releasing Hormone , Leukotriene Antagonists , Ovarian Cysts , Ovarian Diseases , Ovulation Induction , Polycystic Ovary Syndrome , Pregnancy RateABSTRACT
A partir d'une grossesse induite quadruple observee a la clinique MEDICIS de Kinshasa; de l'analyse de 45 dossiers d'enfants issus de grossesses triples et quadruples a l'Hopital Mama Yemo de Kinshasa de 1989 a 1992 et s'appuyant sur une revue de la litterature; les auteurs relevent les divers problemes obstetricaux et pediatriques souleves par les grossesses multiples de haut rang (triples; quadruples) ainsi que les strategies therapeutiques actuellement en cours. Ils en deduisent que les grossesses induites de rang superieur a 2 doivent etre evitees dans la mesure du possible grace a l'utilisation rationnelle et rigoureuse des inducteurs de l'ovulation; au monitorage echographique systematique des cycles induits et au respect strict des criteres de declenchement de l'ovulation