Évaluation de la prescription et de l'utilisation des benzodiazépines dans la ville de Sidi Bel-Abbès / Evaluation of the prescription and use of benzodiazepines in Sidi Bel-Abbes city

Introduction :Une forte consommation des benzodiazépines (BZDs) a été remarquée en dehors parfois des règles de recommandations de prescription, ce qui rend leur consommation un problème majeur de santé publique. La présente étude a eu pour objectif d'évaluer la prescription et l'usage des BZDs dans la ville de Sidi Bel-Abbès. Méthodes-Il s'agissait d'une étude descriptive transversale réalisée du 01 Février 2018 au 30 Juin 2018 évaluant la prescription et l'usage des BZDs dans la ville de Sidi Bel-Abbès au moyen d'un questionnaire distribué aux patients de l'hôpital psychiatrique, du service de psychiatrie du CHU et aux pharmaciens d'officine.Le critère de jugement principal était l'évaluation de la prescription et de l'utilisation des BZDs dans cette ville. La saisie et l'analyse des données ont été réalisées par le logiciel SPSS. Résultats-Au total, 353 patients traités au moins par une BZD ont été inclus dont 178 hommes. Le taux de prescription des BZDs était de 1.10, des jeunes (59,77 %) et des personnes mariées (60,34%) constituaient les consommateurs privilégiés. La prescription était l'apanage des psychiatres, en monothérapie (07,42%), la molé cule la plus fréquemment prescrite était le Bromazépam (31,07%) et la prise noc turne était la plus importante (49,01%). Les BZDs étaient utilisées pour combattre l'insomnie (25,21%), l'anxiété (16,43%), pour une durée de plus d'une année (57,79 %). Conclusion-La prescription et l'utilisation des BZDs dans la ville de Sidi Bel-Abbès s'est avérée importante. L'insomnie et l'anxiété constituaient les principales raisons de leur utilisation, et le Bromazépam était la molécule la plus fréquemment utilisée .

Introduction-A high consumption of benzodiazepines (BZDs) has been noticed so metimes outside the rules of prescription recommendations, which makes their consumption a major public health problem. The present study aimed to evaluate the prescription and use of BZDs in Sidi Bel-Abbès city. Methods-: This was a descriptive cross-sectional study carried out from February 01st, 2018 to June 30th, 2018 evaluating the prescription and use of BZDs in of Sidi Bel-Abbès by means of a questionnaire distributed to patients from the psychiatric hospital, the CHU psychiatry department and community pharmacists. The primary endpoint was the assessment of the prescription and use of BZDs in this city. Data entry and analysis were performed using SPSS software. Results-A total of 353 patients treated with at least one BZD were included, including 178 men. The prescription rate of BZDs was 1.10, young people (59.77%) and married people (60.34%) were the privileged consumers. The prescription was the prerogative of psychiatrists, in monotherapy (07.42%), the molecule most frequent ly prescribed was Bromazepam (31.07%) and night intake was the most important (49.01%). BZDs were used to combat insomnia (25.21%), anxiety (16.43%), for a period of more than a year (57.79%). Conclusion-The prescription and use of BZDs in Sidi Bel-Abbès has proven to be important. Insomnia and anxiety were the main reasons for their use, and Bromazepam was the most molecule frequently used.

The influence of physicians' specialty on prescribing patterns at a general medicine out-patients clinic

Background: Several factors have been identified that influence physicians' prescribing habits. The influence of physician's specialty has not been studied. This study is to determine if there are differences in the prescribing patterns amongst these various specialities that run a general medicine clinic at a tertiary hospital in Ghana. Methods: Data collected from the out-patients clinic attendance records were analysed using WHO Rational Use of Medicines indicators. Analysis of Variance Test was carried out to establish if there was any variance in the prescribing indicators amongst 4 units of Physicians. Results: 678 patient encounters were utilised for this study. The average number of drugs prescribed per encounter was 4.4, drugs prescribed by generic name was 86.9%, patient encounters in which antibiotics prescribed were 6.5% (n= 44) and injections were prescribed in 3.2% (n=22) of patient encounters. 64.0% of all drugs prescribed were from the Ghanaian EML. The unit of the physician did not have a significant effect on the average number of medicines prescribed per patient encounter (F (3, 674) = 2.19, p = 0.088), and the percentage of medicines that were prescribed from the Essential Medicines List (F (3, 674) = 1.52, p = 0.207). The unit the physician belonged to however did have a significant effect at p < 0.05 on the prescription of generic medications (F (3, 674) = 4.79, p = 0.003). Conclusion: The physician units did not differ in their prescribing patterns at the general medicine clinic except for prescription of drugs by their generic names

An assessment of infant medication administration and storage practices in selected communities in the Vhembe District of Limpopo Province, South Africa

Background: Effective infant medication administration and storage is a major public health challenge outlined by the World Health Organization.These challenges may be exacerbated in rural or limited-resource areas.Aim: The aim of this study was to investigate infant medication administration and storage practices.Setting: This study took place in selected communities in the Vhembe District of Limpopo Province, South Africa.Method: Data was collected through 39 semi-structured interviews with infant caretakers and rural health workers. Interviews were recorded when permission was given by participants. Interviews were transcribed and coded using grounded theory and Tesch's model of data analysis. Themes were agreed upon through consensus discussions with the researchers and an independent coder. Results: Six themes that affect current infant medication administration and storage practices in the Vhembe District were identified: access to infant healthcare, the role of health workers, the devices used in the administration of infant medication, reluctance of the infant to take the medication, storage and reuse of infant medication in the rural home and hygiene practices surrounding infant medication administration.Conclusions: Many factors were found to affect infant medication administration and storage practices in in the Vhembe District. Substantial evidence was found to suggest that the relationship between rural health workers and infant caretakers strongly influences these practices: a great amount of reliance and trust is placed in the health worker. Ensuring proper dosage of infant medication in the rural household arose as a main concern of participants. Reuse of medication in the home and home hygiene practices surrounding infant medication administration are areas of potential future research. This future research may further inform recommendations for infant medication administration and storage practices in the Vhembe District

Place de la prescription médicamenteuse dans la prise en charge des pathologies bucco dentaires chez l'enfant au centre dentaire de l'université de Conakry

La prescription est l'acte par lequel le praticien ordonne au patient des produits officinaux ou des préparations magistrales en fonction du poids et de l'âge de l'enfant. L'objectif de cette étude était de Contribuer à l'amélioration de la prescription médicamenteuse chez l'enfant en consultation dentaire à Conakry. Il s'agit d'une étude descriptive menée dans le service dentaire de l'université de Conakry sur une période de 6 mois chez l'enfant âgé de 1 à 12 ans ayant reçu une prescription médicale pour la prise en charge de la pathologie bucco dentaire. Au cours de l'étude nous avons obtenu 38,7% de cas pulpite irréversible et 19,6% de cas de desmodontite. Cependant, 15% d'enfants de notre échantillon ont été prémédiqués ; les classes pharmaceutiques les plus utilisées étaient les antalgiques suivis des antibiotiques avec respectivement 43,5% et 40,3%. La prescription médicamenteuse après l'acte posé était dominée par 43,7% d'antalgiques, 39,6% d'antibiotiques et 16,5% d'anti inflammatoire non stéroïdiens. Le rapport de conformité des molécules prescrites avec le diagnostic posé se résumait à 55,4% de prescriptions conformes contre 44,6% de prescriptions non conformes

Partial-birth abortion ­ is it legally and ethically justifiable? lessons for South Africa

Intact dilation and extraction is a surgical abortion procedure dubbed 'partial-birth abortion', and is deemed infanticide by conservative pro-life advocates in the USA. Despite its salutary (albeit feticidal) nature, as it is arguably less destructive than alternative surgical abortion procedures, intact dilation and extraction is federally banned in the USA. While ostensibly unrelated, the matter is germane to South Africa (SA) as it may inform legislation and legal policy on the regulation of feticidal abortion procedures, since feticide remains unregulated by law. The objective of this article is to understand why intact dilation and extraction is proscribed, and whether proscription is justifiable in SA.Accordingly, the primary legal, medical and ethical arguments underpinning proscription are presented, followed by an examination of the veracity of each argument before gauging whether intact dilation and extraction is constitutionally and ethically justifiable in SA

Antibiotic prescribing practice and adherence to guidelines in primary care in the Cape Town Metro District, South Africa

Background.Knowledge of antibiotic prescribing practice in primary care in South Africa is limited. As 80% of human antibiotic use is in primary care, this knowledge is important in view of the global problem of antibiotic resistance.Objectives. To assess antibiotic prescribing in primary care facilities in the Cape Town Metro District and compare it with current national guidelines, and to assess the reasons why prescriptions were not adherent to guidelines.Methods. A retrospective medical record review was performed in April/May 2016. Records of all patients seen over 2 days in each of eight representative primary care facilities in the Cape Town Metro District were reviewed. The treatment of any patient who raised a new complaint on either of those days was recorded. Prophylactic antibiotic courses, tuberculosis treatment and patients with a non-infection diagnosis were excluded. Treatment was compared with the Standard Treatment Guidelines and Essential Medicines List for South Africa, Primary Healthcare Level, 2014 edition.Results. Of 654 records included, 68.7% indicated that an antibiotic had been prescribed. Overall guideline adherence was 45.1%. Adherence differed significantly between facilities and according to the physiological system being treated, whether the prescription was for an adult or paediatric patient, and the antibiotic prescribed. Healthcare professional type and patient gender had no significant effect on adherence. The main reasons for non-adherence were an undocumented diagnosis (30.5%), antibiotic not required (21.6%), incorrect dose (12.9%), incorrect drug (11.5%), and incorrect duration of therapy (9.5%). Conclusions. This study demonstrates poor adherence to guidelines. Irrational use of antibiotics is associated with increased antibiotic resistance. There is an urgent need to improve antibiotic prescribing practice in primary care in the Cape Town Metro District

Threats posed by stockpiles of expired pharmaceuticals in low- and middle-income countries: a Ugandan perspective

In some low- and middle-income countries, the national stores and public-sector health facilities contain large stocks of pharmaceuticals that are past their expiry dates. In low-income countries like Uganda, many such stockpiles are the result of donations. If not adequately monitored or regulated, expired pharmaceuticals may be repackaged and sold as counterfeits or be dumped without any thought of the potential environmental damage. The rates of pharmaceutical expiry in the supply chain need to be reduced and the disposal of expired pharmaceuticals needs to be made both timely and safe. Many low- and middle-income countries need to: (i)strengthen public systems for medicines' management, to improve inventory control and the reliability of procurement forecasts; (ii) reduce stress on central medical stores, through liberalization and reimbursement schemes; (iii) strengthen the regulation of drug donations; (iv) explore the salvage of officially expired pharmaceuticals, through re-analysis and possible shelf-life extension; (v) strengthen the enforcement of regulations on safe drug disposal; (vi) invest in an infrastructure for such disposal, perhaps based on ultra-high-temperature incinerators; and (vii) include user accountability for expired pharmaceuticals within the routine accountability regimes followed by the public health sector

Faut-il prescrire ou proscrire les médicaments chez la femme enceinte?

La prescription de médicaments au cours de la grossesse est très souvent une source d'inquiétude tant pour le professionnel de santé que pour la femme enceinte elle-même.La question du rapport bénéfice/risque pour la mère comme pour l'embryon ou le foetus ne semble pas toujours aussi évidente à résoudre et les mises en garde souvent non spécifiques des notices des médicaments peuvent apparaître difficiles à interpréter. C'est pourquoi, devant cette situation, plus que devant tout autre, l'expérience clinique et les connaissances pharmacologiques sont indispensables. Affirmer l'absolue innocuité d'un médicament est quasiment impossible, par contre il est facile, d'avoir une attitude prudente avec les médicaments récents et par conséquent mal évalués pour ne garder que les anciens, efficaces et reconnus pour leur faible tératogénicité ou toxicité. Le propos de cette revue est de fournir différentes informations précises et objectives permettant de faire un choix juste et raisonné de médicaments utilisables chez une femme enceinte

Determinants of antibiotic prescription in paediatric patients: The case of two hospitals in Maputo, Mozambique

Background. The need for healthcare in paediatric patients is often due to respiratory diseases, acute diarrhoea and viral fever, which suggests a limited need for the use of antibiotics.Objectives. To identify the determinants of antibiotic prescription in hospitalised paediatric patients in Mozambique.Methods. A cross-sectional study was conducted between January and June 2015. A total of 454 medical prescriptions and clinical records of children aged 0 - 14 years from Hospital Central de Maputo (HCM) and Hospital Geral de Mavalane (HGM) were analysed.Results. Antibiotics were used in 97.6% of the patients, with no significant differences (p>0.05) in the prescription rates of the hospitals. The most commonly used antibiotics were beta-lactams (57.3%), aminoglycosides (28.3%) and co-trimoxazole(9.4%). Antibiotics were prescribed in all cases of bronchopneumonia, fever, sepsis and acute gastroenteritis. For malaria and undefined diagnoses, antibiotics were prescribed 97.8% and 99.3% of cases, respectively. It was clear that most severe clinical conditions (odds ratio (OR) 9.06; 1.13 - 12.14) and age <5 years (OR 5.47;1.54 - 7.60) were treated with antibiotics.Conclusion. The prescription of antibiotics for paediatric patients at both HCM and HGM was largely influenced by patients' clinical condition and age. It showed that physicians used an empirical approach, in the absence of laboratory tests, often leading to unnecessary antibiotic treatments with negative causative effects. Physicians should be encouraged to use an evidence-based approach for managing the cases correctly

Acteurs de sante dans la prise en charge de l'asthme au Burkina Faso

Objectif : Identifier les entraves a la meilleure prise en charge du patient asthmatique par les acteurs de la sante a Ouagadougou. Methode: Etude transversale a visee descriptive de Janvier a decembre 2012; associee a une revue de la litterature portant sur le role des acteurs de sante dans la prise en charge de l'asthme. Resultat: La technique de demonstration de la prise de l'aerosol doseur etait maitrisee chez 46 des medecins. Une ordonnance medicale etait exigee par 9 des pharmaciens avant la delivrance des medicaments asthmatiques. La verification de la conformite de la prescription medicale etait faite par 30 des pharmaciens; la demonstration de la prise de l'aerosol doseur a l'officine etait assuree par 73;6 des pharmaciens et bien maitrisee par 34;5. Dans le cadre du traitement de l'asthme; 43;2 des infirmiers savaient que les bronchodilatateurs et les corticoides etaient les medicaments les plus utilises. Les bronchodilatateurs inhales d'action rapide etaient recommandes par 40;6 des infirmiers dans l'asthme intermittent; cette prescription n'est pas conforme aux recommandations de la GINA. Conclusion : Un besoin de formation/recyclage est exprime par la quasi totalite des acteurs de sante intervenant dans la prise en charge de l'asthme au Burkina Faso

Evaluation of Antiulcer Properties of Ethanolic and hot Aqueous Stem Extracts of Synclisia Scabrida on Experimentally Induced Ulcer Models in Albino Mice

The treatment of peptic ulcer disease poses therapeutic challenges to both patients and physicians alike because of the tendency of ulcers to relapse. Drugs used in the treatment of this disease are either costly or are associated with high incidence of adverse effects. Synclisia scabrida is a plant used in ethnomedicine for the treatment of various forms of stomach disorders and menstrual pains. The medicinal properties of the plants are claimed to reside in the roots; stems; and the leaves. Aim : This study; therefore; is to verify this claim and elucidate the probable mechanism of action by using crude stem extracts of this plant on drug- and stress-induced ulcer models in albino mice. Materials and Methods : Crude ethanol and hot water extracts; EE and HWE respectively; of the stem were prepared. These extracts were fractionated and separated by chromatographic methods and the fractions pooled together as fractions (PF-1; PF-2; PF-3 respectively) based on their chromatographic mobility and color reactions. Phytochemical analysis was done on the extracts. Ulcer models were induced in albino mice by means of indomethacin; histamine; and stress after prior cytoprotection with orally administered crude extracts and control (cimetidine). Results : Phytochemical analysis of the crude extracts and their fractions revealed the presence of cardiac glycosides (+++); tannins (+++); saponins (+); flavonoids (++); carbohydrates (++) and alkaloids (+++). Acute toxicity study on the crude extracts and their fractions revealed relative safety at the dose of 5000 mg/kg. The crude extracts (EE and HWE) and their fractions (PF-1; PF-2; PF-3) significantly (P = 0.001) protected against indomethacin-; histamine- and stress-induced ulcers. The decrease in GIT motility produced by these extracts was comparable to that produced by atropine sulfate. Conclusion : The findings suggest that these extracts of Synclisia scabrida possess antiulcer and antispasmodic properties; which justify the claims for its use in the treatment of various forms of stomach disorders

Epidemiology of drug abuse treatment in South Africa

Background. The aim of the study was to explore the epidemiology of drug abuse treatment in South Africa. Methods. Treatment demand statistics were analysed from South African National Council on Alcoholism and Drug Dependence and the South African Community Epidemiology Network on Drug Use records; and a rapid situation assessment was conducted. Twenty-one key informant interviews were conducted in all 9 provinces among provincial substance abuse co-ordinators, and one manager per treatment centre from a sample of treatment centres. Three focus groups were conducted and 46 self-administered questionnaires were distributed among inpatients at 2 selected treatment centres in Free State and North West provinces. Qualitative data were analysed using grounded theory, and quantitative data analysed using SPSS. Results.Treatment records show that the most frequent substance of abuse was alcohol (51), followed by cannabis (21), crack/cocaine (9.6), heroin/opiates (7.9), methamphetamine (Tik) (4.5), prescription/over-thecounter drugs (2.0), and cannabis/mandrax (1.7). More substance abusers were male, of lower education, white or black, than were female, more highly educated; coloured and Indian/Asian. Key informant interviews showed that females are the 'hidden' substance abusers and tend not to be identified in research statistics and at treatment centres. Poverty, unemployment, lack of recreational facilities, being surrounded by substance abusers; and long work shifts were also mentioned as factors contributing to substance abuse. The age of initiation of substance abuse using non-drugs such as glue was 9 years old; alcohol 10 - 12 years old, dagga 11 -12 years old, poly-drug use (alcohol, tobacco and dagga) 14 years old, and harder drugs such as cocaine and heroin at 16 - 17 years old, as reported by key informants. Family care and support, improved socio-economic conditions and increased law enforcement would help to discourage substance abuse. Conclusion. Prevention interventions and policies in South Africa should focus on reducing substance abuse by targeting the 'at risk populations' identified in this study

Evaluation de la qualite de la prescription et de la dispensation des Combinaisons therapeutiques a base d'artemisinine (CTA) dans le district de Bamako; Mali

Entre avril et juillet 2008; nous avons mene une etude transversale sur la qualite de la prescription et de la dispensation des Combinaison Therapeutique a base d'Artemisinine (CTA) dans le traitement de l'acces palustre simple dans certains centres de sante et les officines ou depots de medicaments du district de Bamako. Au total; 52 prescripteurs; 72 dispensateurs et 90 patients ont ete inclus. L'etude a consiste a l'interview des sujets. L'enquete a revele que les CTA constituaient le traitement de premiere intention du paludisme chez les prescripteurs (75) et des dispensateurs (78;8). Cependant; 57;61des ordonnances contre le paludisme ne contenait pas de CTA. Les CTA recommandees par le programme national de lutte contre le paludisme (PNLP) etaient connues par 59;7des dispensateurs et 73;1des prescripteurs. La majorite des prescripteurs (71;15) et des dispensateurs (84;72) etaient favorables aux recommandations du PNLP. Beaucoup de patients (41;30) ne comprenaient pas du tout la posologie des CTA prescrites. Presque toutes les ordonnances contenant des CTA etaient prescrites en DCI (97;72; n = 44). Les prix des CTA ont varie entre 140 et 3 380 FCFA avec une moyenne de 750 FCFA. D'apres les reponses des prescripteurs et des dispensateurs; les CTA constituaient leur premier choix. Cependant; 57;61des ordonnances contre le paludisme ne contenait pas de CTA. La majorite des prescripteurs (71;15) et des dispensateurs (84;72) sont favorables aux recommandations du PNLP. Le cout moyen des ordonnances contenant les CTA etait 750 FCFA avec des extremes allant de 140 a 3680 FCFA. Une bonne utilisation des CTA s'avere imperative pour garantir leur efficacite et retarder voire eviter l'emergence de la resistance des parasites du paludisme a ces molecules

Mieux prescrire l'amoxicilline (1ere partie)

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