Effect of heavy cigarette and water pipe smoking on antioxidants and lipids in Sudanese male smokers: a case-control study

Background: Tobacco smoking is a source of many toxins such as free radicals, mutagenic substances as well as cause for developing cardiovascular diseases (CVD), particularly atherosclerosis. This study aims to assess the impact of smoking on antioxidants in Sudanese male smokers. Methods: Cases were 85 and 48 men who smoke cigarettes (CS) and water pipe (WPS) respectively and they were compared with matching 50 non-smoking controls. Blood samples were collected and following parameters: Glutathione peroxidase, Superoxide dismutase, Total cholesterol, Triglyceride, LDL, HDL, Paraoxinase, and Malondialdehyde were measured. Results: There were no significant differences in biochemical parameters between light CS and WPS compared to controls. In heavy smokers of both WPS and CS, the TC, TG, LDL, and MDA were higher than controls (p>0.05), GPx, SOD, HDL, and PON were lower in smokers than controls (p>0.05). In both groups of smokers, HDL, GPx, SOD, and PON were inversely correlated with duration of smoking (p>0.05), also, HDL was positively correlated with SOD and GPx (p>0.05). Moreover, GPx and SOD were correlated with each other in both groups of smokers (p>0.05). Conclusion: In Sudanese male smokers' biochemical profile disturbances suggest that heavy smoking was leading to developing CVD, particularly WPS

Association between serum lipid profile, body mass index and osteoporosis in postmenopausal Sudanese women

Background: Epidemiological observations suggest links between osteoporosis and the risk of acute cardiovascular events. Whether the two clinical conditions are linked by common pathogenic factors or atherosclerosis per se remains incompletely understood. The reduction of bone density and osteoporosis in postmenopausal women contributes to elevated lipid parameters and body mass index (BMI). Objective: To investigate the relationship between serum lipid profile, BMI and osteoporosis in postmenopausal women. Materials and Methods: A prospective analytical case control-study conducted in Khartoum north hospital at Khartoum city, capital of the Sudan from April 2017 to March 2018 after ethical approval obtained from the local Research Ethics Committee of Faculty of Medical Laboratories, Alzaeim Alazhary University on the committee meeting number (109) on Wednesday 15th February 2017. A written informed consent was obtained from all participants to participate in the study.Two hundred postmenopausal women were enrolled in the study. The age was studied in one hundred osteoporosis postmenopausal women as a case group and one hundred non-osteoporosis postmenopausal women as control group. The serum lipid profiles were estimated using spectrophotometers (Mandry) and BMI calculated using Quetelet index formula. The data were analysed using SPSS version 16. Results: The BMI, serum total cholesterol, triglyceride, HDL and LDL in case group respectively were (24.846±2.1647, 251.190±27.0135 mg/dl, 168.790 ±45.774 mg/dl, 50.620 ± 7.174 mg/dl, 166.868 ±28.978 mg/dl). While the BMI, serum total cholesterol, triglyceride, HDL and LDL in control group respectively were (25.378 ±3.8115, 187.990 ± 26.611 mg/dl, 139.360±20.290 mg/dl, 49.480 ±4.659 mg/dl, 111.667 ±28.0045 mg/dl). All serum lipid profiles significantly increased (p=0.000) in the case group compared to the control group, except serum HDL was insignificant different between the case and control group and also BMI was insignificant different between the case and control group. There was a positive Pearson's correlation between BMD and serum total cholesterol (r= 0.832, P<0.01), serum LDL (r = 0.782, P<0.01) and serum triglyceride (r = 0.72, P<0.01). Conclusions: Osteoporotic postmenopausal women had a significant increase in serum lipid profile and BMI. Moreover, we found a positive link between women with cardiovascular diseases and stroke

Misconceptions and associated factors of COVID-19 infection among internally displaced persons in Sudan

Coronavirus disease 2019 (COVID-19) is a global public health threat that has spread rapidly and caused morbidity and mortality worldwide. Reducing the myths about infectious diseases is vital for controlling transmission. This study explored the level of misconceptions and associated factors of COVID-19 among internally displaced persons in Sudan. This study is a cross-sectional, descriptive design and community-based study. We collected the data using a self-administered questionnaire via the convenience sampling technique among internally displaced persons in the camps of Zalingei town in the central Darfur region of Sudan. The total mean score of the respondents' misconception was 3.1725 (SD=0.59) with 63.2%, indicating moderate misunderstanding of COVID-19. Multiple linear regression revealed the independent variables together had a significant impact on a misconception, F(14,116)=2.429, p<0.005. The regression model explains 22.7% of the variance in misunderstanding. Analysis of the influence of single factors on the dependent variable showed that people aged 31­40 years had significantly higher levels of misconception, 0.381 (t=2.116, p<0.037), than those aged over 60 years, and university graduates had considerably lower levels of misunderstanding, −0.061 (t=−2.091, p<0.03) than non-graduates. This study found a moderate level of misconception of COVID-19. Non-graduates had higher levels of misunderstanding than graduates. The results suggest that an education campaign should focus on people with low levels of education to correct their misconceptions regarding the prevention of COVID-19 infection

Adherence to Immunosuppressive Medications in Kidney Transplant Patients at Three Centers in Khartoum State, Sudan: A Cross-sectional Hospital Study

Background: Graft survival post-kidney transplantation is of paramount importance to patients and nephrologists. Nonadherence to immunosuppressive therapy can be associated with deterioration of renal function and graft rejection. This study aimed to evaluate the adherence to immunosuppressive medications in kidney transplant patients at three centers in Khartoum, Sudan. Methods: In this descriptive cross-sectional hospital-based survey, 277 post-kidneytransplant patients were recruited. Data were collected using a questionnaire and analyzed using the SPSS v.23. Our scoring method was calculated based on Morisky Medication Adherence Scale (MMAS-8) related to immunosuppressive medications and was expressed as questions in the questionnaire; every correct answer was given one mark, then the marks were gathered and their summation was expressed. Results: Overall, 33% ,45%, and 22% of the studied participants reported high, medium, and low adherence, respectively. The major factor for nonadherence was forgetfulness affecting 36.1% of those who did not adhere. The cost of the immunosuppressive medications did not negatively affect any of the participants' adherence (100%). However, a significant association was seen between adherence and occupational status, duration of transplantation, shortage of immunosuppressants, recognizing the name of immunosuppressant, side effect, and forgetfulness (P-values = 0.002, 0.01, 0.006 , 0.000, 0.022, and 0.000, respectively). Logistic regression analysis showed a significant association with occupational status, side effects, and forgetfulness.

Assessment of Variation in Clinical Presentation of Visceral Leishmaniasis Among Patients Attending the Tropical Diseases Teaching Hospital in Sudan

Background: Visceral leishmaniasis (also known as Kala-azar) is a systemic parasitic infection with many clinical presentations. The present study assesses the variation in presentations among patients who attended the Tropical Diseases Teaching Hospital (TDTH) in Khartoum, Sudan. Methods: This analytical cross-sectional, hospital-based study was conducted at the TDTH between November 2019 and September 2020. Medical records of patients who presented at the TDTH were reviewed using a structured data extraction checklist. The Chi-square test was used to determine the associations between sociodemographic and clinical presentations of patients. P-value < 0.05 was considered as statistically significant. Results: Out of 195 patients, 79.5% were male and 48.2% were <31 years old. Fever was the main clinical presentation (90.2%) while 53.3% presented with weight loss and 72.3% and 39% presented, respectively, with splenomegaly and hepatomegaly. HIV was detected in 4.6% of the patients. RK39 was the main diagnostic test. We found a significant association between the abdominal distention and the age of the patients (P < 0.05) ­ age groups 11­20 and 41­50 years were more likely to present with abdominal distention than other age groups. Conclusion: There is no exact clinical presentation or routine laboratory findings that are pathognomonic for visceral leishmaniasis; therefore, it should be considered in the differential diagnosis of any patient with fever, weight loss, and abdominal distention, and among patients with HIV.

COVID-19 in Sudan: Will the mitigation Efforts win against the Virus?

Background: The COVID-19 pandemic has hit hard both the affluent and poor countries. The objective of this article is to highlight the efforts of the Ministry of Health in Sudan in mitigating the pandemic and reflecting on counteracting factors. Methods: We traced the reports and plans of the Federal Ministry of Health and looked at the models projecting the pandemic in Sudan. Results: The fundamental plan of the government of Sudan to cope up with the pandemic included the control of the source of infection, blocking transmission, and preventing the spread. The response mechanism had a multi-sector approach with involvement of government, civil society organizations, and non-governmental organizations (NGOs). The action plans involved protocols for COVID-19 diagnosis and treatment, surveillance, epidemiological investigation, and management of case contacts. However, several factors continued to jeopardize the mitigation efforts of these plans. At the time of writing this article (at the end of the May 2020), there were about 4,000 confirmed cases, 300 recoveries, and 170 deaths. Although these numbers are below the projected numbers in many proposed models, in the light of the limited testing capacity, case identification and contact tracing, the exact situation might not be ascertained. Conclusion: Sudan has prepared a national plan to prevent and contain COVID19 pandemic. However, tremendous challenges are opposing these efforts. The poor health infrastructure, fragility of the health system, and the economic crisis are the major obstructions

Integrating immunization services into nutrition sites to improve immunization status of internally displaced persons' children living in Bentiu protection of civilian site, South Sudan

Introduction: the protracted war in South Sudan has led to severe humanitarian crisis with high level of malnutrition and disruption of the health systems with continuous displacement of the population and low immunization coverage predisposing the population to vaccine preventable diseases. The study aimed at evaluating the effect of integrating immunization services with already established nutrition services on immunization coverage in resource-constrained humanitarian response.Methods: a community and health facility based interventional study involving integration of immunization into nutrition services in two Outpatient Therapeutic Program(OTP)centers in Bentiu PoC between January-December 2017. The main hypothesis was that inclusion of immunization services during nutrition services both at the OTP and community outreaches be an effective strategy for reducing missed opportunity for immunizing all eligible children accessing nutrition services. Data analyzed using STATA version 15 and bivariate analysis using logistic regression was conducted to identify predictor of missed vaccinations.Results: integration of immunization into the nutrition services through the OTP centres increased the number of children immunized with various antigens and the dropout rate was much lower and statistically significant among children who received immunization at the OTP centers than those in the Primary Health Care Centers (PHC Centers) in the study sites. Children who were vaccinated at the OTP centre in sector 2 were 45% less likely to miss vaccination than those vaccinated at the PHCC (OR: 0.45; 95%CI:0.36- 0.55), p<0.05 while those vaccinated at the OTP sector in sector 5 were 27% less likely to miss vaccination than those vaccinated at the PHCC (OR: 0.27; 95%CI: 0.20 -0.35) p<0.05).Conclusion: this study indicated that immunization coverage improved effectively with integration with nutrition services as a model of an integrated immunization programme for child health in line with the Integrated Management of Childhood Illnesses (IMCI) and the Global Immunization Vision and Strategy (GIV)

Congenital heart disease in a cohort of Sudanese patients with cleft defects

Background and objectives:Cleft defects are among the most visible congenital defects worldwide and congenital heart disease (CHD)being one of the most common associated anomalies. This study aimed to assess the prevalence of CHD among a cohort of Sudanese patients with cleft lip and/or palate.Patients and Methods:All patients who presented to Soba University Hospital with cleft lip and/or palate from March 2009 toMarch 2015 were included.Results:Out of 381 patients included; 168 patients (44%) had cleft lip and palate (CLP), 156 (41%) had cleft lip (CL)and isolated cleft palate (CP) was found in 57 patients (15%). Facial dysmorphic features were identified in 57 (15%) and cardiac defects in 42 (11%) patients. Ventricular septal defect (VSD) was diagnosed in 16 patients (38%), and ASD in 12 (30.9%). Other macroscopic anomalies were identified in 57 patients (15%)and were associated with CHD (P<0.001). Significant association was found between the type of cleft andCHD (P<0.002), as cardiac defects were maximally observed among CP cases (21%) followed by CLP cases (13%) then CL cases (5.12%). Significant association was also found between facial dysmorphicoccurrence and CHD (P < 0.001).Conclusion:CHD is a common anomaly in cleft population. The pattern of CHD is consistent with the literature withVSD being the most frequent. The cardiac defects are most prevalent in CP group. Echocardiography isjustified for screening of CHD due to the relatively higher incidence of CHD among clefts patients than ingeneral population

Morphological patterns of anaemia among pregnant women from Sudan

Background: Morphological patterns of anaemia in pregnancy are considered essential for classification, diagnosis and management of patients, especially in regions with high maternal mortality like Sudan.Objectives: This study evaluated morphological patterns of anaemia among pregnant women in Sudan and morphological differences across characteristics of participants.Methods: This cross-sectional study was conducted from September 2016 to February 2017. A total of 200 women were selected according to specific criteria. Laboratory tests were performed for complete blood count, blood smears were performed for morphology and vitamin B12, folate and iron levels were measured. Participants were classified as: normochromic normocytic, microcytic hypochromic, macrocytic or dimorphic. Further classification based on haemoglobin levels was also performed.Results: A total of 116 participants (58%) had a dimorphic pattern, followed by 50 participants (25%) with a microcytic hypochromic pattern, 20 participants (10%) with a macrocytic pattern and 14 participants (7%) with a normochromic normocytic pattern. Participants with the dimorphic pattern also had low levels of iron and folate. The majority of dimorphic participants presented with mild anaemia, whereas the majority of participants with the microcytic hypochromic pattern presented with moderate or severe anaemia. A high percentage of participants in late pregnancy had the dimorphic pattern, and there were significant differences in the degree of anaemia by parity, gestational age and regular intake of haematinic supplements.Conclusion: The most frequent morphological pattern of anaemia in this study was dimorphic, followed by microcytic hypochromic, macrocytic and normochromic patterns. Morphological patterns appeared to predict types of vitamin and mineral deficiency and the degree of anaemia

Using WhatsApp smartphone application to monitor INR in patients on Warfarin: first experience with 21 patients

Anticoagulation with warfarin is under-prescribed in eligible patients. The quality of anticoagulation as measured by Time in Therapeutic Range (TTR) is below the 60-70% standard in clinical practice (outside anticoagulation clinics) with lower rates in SubSaharan Africa when compared with Western Europe, Canada and the United States. WhatsApp is a free smartphone application that is increasingly used for telemedicine applications. In this retrospective study, we reviewed the use of WhatsApp for physician-patient communication of INR results and Warfarin dose adjustments. From March 5th, 2018 to May 15th, 2019, all patients (n=938) attending a private Cardiology clinic were offered WhatsApp as a means of direct communication with the Cardiologist on an as needed basis. 21 (2.2%) used it for INR reporting and Warfarin dose adjustment. The median age was 62 years, with a male to female ration of 10:11. The median TTR was 37% by Linear Interpolation, and 42.9% by percentage of therapeutic INRs. The median follow-up duration was 82 days. 23% of patients managed to achieve TTR of more than 72%. Most patients (61.9%) continued on warfarin during the study period, 9.5% switched to a Directly Acting Oral Anticoagulant, 9.5% stopped Warfarin due to bleeding while on therapeutic INR, 14.2% switched to another provider for INR monitoring, 9.5% were lost to follow-up. Smartphone technology may provide a solution for reduced Warfarin prescription for eligible patients, with some patients (23% in this study) achieving TTRs of more than 72%. However, overall TTR rates remained low in this study

Benign effects of Helicobacter pylori in gastric mucosa among symptomatic Sudanese patients

Infection with Helicobacter pylori is a worldwide problem. It plays an important role in gastric malignancies.The pathogenesis of gastric malignancies involves multistep progression changes in gastric mucosa and the Helicobacter pylori infections is the first step in most of cases.Aim:The aims of this study were to clarify the benign changes in gastric mucosa after Helicobacter pylori infection;to evaluate the endoscopic and histological patterns of infection and to correlate endoscopic findingwith histopathological parameters.Materials and Methods:A descriptive, retrospective study was done in Soba University Hospital between January 2009 - February2013. Paraffin-embedded blocks, Giemsa and Haematoxylin and Eosin-stained slides, were obtained from 50 cases of Helicobacter pylori-associated chronic gastritis and examined under light microscopy. The clinical information and endoscopy findings were obtained from the records. The data was analyzed using Statistical Package for Social Sciences Software.Results:The most common affected age group was between 40-60 years. The prevalence of infection was equal in males and females. The commonest endoscopic finding was inflammation of gastric mucosa. Most patients presented with moderate degree of colonization; 62% of patients presented with a severe degree of chronic inflammation. There was a significant statistical correlation between the degree of Helicobacter pylori colonization and the degree of chronic inflammation (p<0.05). Most patients presented with severe degree of active gastritis. A significant correlation was found between the degree of chronic inflammation and degree of activity. The prevalence of lymphoid follicles in a single biopsy specimen from antral mucosa was 36%.The dysplasia was seen in 12%; eosinophilia 8%; atrophy 8% and intestinal metaplasia in 6% of the cases.No significant correlation was found between the endoscopic findings and histological findings.Conclusion:Helicobacter pylori infection causes chronic active gastritis and it has a role in the development of lymphoid follicles, intestinal metaplasia, atrophy and dysplasia

Congenital heart disease in a cohort of Sudanese patients with cleft defects

Background and objectives: Cleft defects are among the most visible congenital defects worldwide and congenital heart disease (CHD) being one of the most common associated anomalies. This study aimed to assess the prevalence of CHD among a cohort of Sudanese patients with cleft lip and/or palate. Patients and Methods: All patients who presented to Soba University Hospital with cleft lip and/or palate from March 2009 to March 2015 were included. Results:Out of 381 patients included; 168 patients (44%) had cleft lip and palate (CLP), 156 (41%) had cleft lip (CL) and isolated cleft palate (CP) was found in 57 patients (15%). Facial dysmorphic features were identified in 57 (15%) and cardiac defects in 42 (11%) patients. Ventricular septal defect (VSD) was diagnosed in 16 patients (38%), and ASD in 12 (30.9%). Other macroscopic anomalies were identified in 57 patients (15%) and were associated with CHD (P<0.001). Significant association was found between the type of cleft and CHD (P<0.002), as cardiac defects were maximally observed among CP cases (21%) followed by CLP cases (13%) then CL cases (5.12%). Significant association was also found between facial dysmorphic occurrence and CHD (P < 0.001). Conclusion: CHD is a common anomaly in cleft population. The pattern of CHD is consistent with the literature with VSD being the most frequent. The cardiac defects are most prevalent in CP group. Echocardiography is justified for screening of CHD due to the relatively higher incidence of CHD among clefts patients than in general population

Testicular cancers in Radiation and Isotope centre, Khartoum, Sudan: a retrospective study

This is a retrospective study of 44 cases of testicular cancers treated at the Radiation and Isotopes Center ofKhartoum (RICK).The mean age was 29.9 years. Six patients (13.6%) had undescended testicles; 24 patients (54.4%) presented with stages three and four. Only 20 patients (45.4%) survived for five years and . more

Reliability of physiology MCQs' examinations at the Faculty of Medicine, University of Khartoum

Background: One of the major challenges that face exam constructors is generating highly reliable exams. An assessment cannot be viewed as valid unless it is reliable. Test reliability, which is the best single measure of test accuracy, is the extent to which test results are consistent, stable, reproducible and free of error variance. Reliability isinfluenced by internal factors related to exam construction, as well as external factors which depend on the situation of test administration. Objective: To estimate the reliability of multiple choice questions (MCQs) of physiology exams as part of an overall quality assessment at the Faculty of Medicine, University of Khartoum.Methods:Reliability influential factors related to exam construction and administration were controlled and catered for by departmental and administrative staff according to the exam regulations of the faculty. Remark software was used for post-examination analysis of scores of ten consecutive summative physiology MCQ exams at the Faculty of Medicine, University of Khartoum. The number of the examinees who sat for each of the ten exams ranged from 332­359. In addition to reliability coefficients, item difficulty index (DIF I) and point-biserial correlation coefficient (rpbis)as a measure of item discrimination ability, were calculated as part of item analysis results.Results:The study revealed high exams' reliability (0.84-0.95) as measured by different formulas [Kuder-Richard-son Formulas (KR-20, KR-21) and Cronbach's-Alpha], and low standard error of measurement/SEM (3.073.80).Factorswhichcontributed to the high reliability of our ten exams were: their high discrimination power (0.32-0.47), their recommended mean difficulty (48.62-65.67%), and the relatively large numbers of items (60­80) per each exam.Conclusion:The high exams reliability of this study was an indicator of the precise control of external and internal factors influencing reliability. The most important contributing factor was the proper construction of exams with high quality items; in addition to careful exam administration and meticulous scoring system

Madurella mycetomatis causing multiple mycetoma lesions: a rareclinical presentation

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Traditional medicinal plants used for the treatment of diabetes in the Sudan : A review

The prevalence of metabolic disorders such as diabetes among population is of increasing concern worldwide. Sudan is a developing country, where several areas frequently depend on folk medicine. Several herbal preparations have been used in folklore practice in Sudan for the management of diabetes with claims asserting their hypoglycemic effect. Basic research relating to these plants are reviewed in this paper with the intention to highlight their therapeutic potential for the treatment of diabetes and promote their regular use in Sudan. Ethnobotanical information was obtained by an assessment of the available literature in electronic data bases with publications describing the medicinal plants used for the treatment of diabetes. In this review paper, different parts of 38 plant species, are described that are used in the Sudanese traditional medicine and belong to 35 genera and 23 families. Thirty three plants have been documented in scientific literature to possess in vivo antidiabetic activity and only one was ineffective in lowering blood glucose level, namely Striga hermonthica. Many of the plants in the study review have been studied in in vitro models (such as α-amylase or α-glucosidase inhibition) in an effort to explain some of their biomedical interaction. The role of isolated bioactive compounds like trigonelline and 3, 5-dicaffeoylquinic acid in diabetes management is also evaluated in the present review. Ten plants original from Sudan have been already used in clinical trials for the treatment of type 2 diabetes. This review provides useful information on the characterization of such herbal medicines that are utilized in the Sudanese traditional medicine for the control of metabolic syndromes such as diabetes

Prognosis in heart failure with preserved ejection fraction

Heart Failure with preserved Ejection Fraction (HFpEF), like other heart failure syndromes, is heterogeneous in etiology and pathophysiology, rather than a single disease. HFpEF may account for about half of all patients with heart failure. Patients have symptoms and signs of HF with normal or near normal left ventricular EF (LV EF>50 %). The classical risk factors for developing HFpEF include advanced age and co-morbidities, notably hypertension, atrial fibrillation, and the metabolic syndrome. When complicated by increasing congestion requiring hospital admission, the prognosis is poor; 30% or more of such patients will die within 1 year (nearly two-thirds die from cardiovascular causes). Patients with chronic stable symptoms have a better prognosis. Patients with HFpEF represent an important group of patients presenting in clinical practice with HF. Overall, it appears that patients with HFpEF are at lower risk of death than patients with HFrEF, although mortality remains high in both groups. Application of the same therapeutic hypotheses that have been successfully utilized among patients with HFrEF have not been demonstrated to result in improved survival

Thromboembolic events in Sudanese patients with rheumatic mitral stenosis

Background: Rheumatic mitral stenosis (MS) is a common problem in the Sudanese community, usually affecting the younger population. It can be a crippling condition with many complications, thromboembolism being one of the most serious. Objective:The aim of this study is to quantify the prevalence of thromboembolism and to identify its risk factors in Sudanese patients with MS at Ahmed Gasim Cardiac Centre. Methodology:Records of patients admitted from Jan 1999-Jan 2003, were retrospectively reviewed and data from various clinical and echocardiographic variables were recorded. Results:A total of 412 patients were studied, 142 (34.5%) were males, 270 (65.5%) were females. There were no significant differences in the gender (P = 0.606) or severity of symptoms between patients with and without thromboembolism. Patients with thromboembolism were older (P < 0.016), had more frequent atrial fibrillation (P = 0.017), smaller mitral valve area (P = 0.021) and higher pulmonary artery pressure (P = 0.012) compared to patients without thromboembolism. Dilated left atrial (LA) size was significantly associated with thromboembolism (P = 0.034), spontaneous echo contrast (P = 0.048) and the presence of LA or left atrial appendage (LAA) thrombus (P = 0.029). The presence of LA/LAA thrombus was significantly associated with both thromboembolism (P = 0.05) and spontaneous echo contrast (P < 0.0001). Transoesophageal echocardiography was more sensitive in detecting both spontaneous echo contrast (P < 0.0001) and LA/LAA thrombus (P < 0.0001) than transthoracic echocardiography. Conclusion: These results highlight the clinical and echocardiographic risk factors for thromboembolism, the sensitivity of transoesophageal echo for assessment of those patients, and the need for early referral for percutaneous transvenous mitral commisurotomy (PTMC)

Health hazards related to Soba sewage treatment plant, Sudan

The aim of this study was to determine the health hazards acquired by the residents nearby Soba sewage treatment plant. A descriptive cross-sectional study was carried out in Soba locality, Khartoum, Sudan. An interviewer-administrated questionnaire was assigned to 462 residents of the area living in four geographically distributed squares around the sewage plant. The data was analyzed in SPSS; Cronbach's alpha reliability scale of measurement was used to check the internal validity of six variables related to the quality of life. A logistic regression analysis was used to assess the relationship between the health hazards and the quality of life. Among the 462 residents, difficulty in breathing (37.9%) and nausea (37.2) were the principal health hazards. Moreover, the residents had a satisfactory level of awareness (88.7%) about the health hazards. The utmost impact on the quality of life was psychological (97.2%). It was statistically correlated with the reported factors, which impacted the quality of life in the district as revealed by the Cronbach's alpha reliability test with absenteeism (P=0.026), disability (P=0.014), socialization (P=0.032) and death (P=0.016). A logistic regression analysis revealed chemical hazards had a statistically significant association (P<0.05) with quality of life of the residents of Soba district. The study strongly entails the fact that sewage treatment plants crave exceptional consideration from the concerned responsible authorities, together with the fact that the evolved health threats should be confronted with immense responsibility as soon as possible