Blood Uric Acid Level as a Marker of Increased Risk of Eclampsia in Severe Pre-Eclamptic Patients: A Cross-Sectionnal Study in two Tertiary Hospitals in Yaounde; Cameroon

BACKGROUND. Eclampsia is the most dangerous maternal complication in hypertensive disorders of pregnancy (HDP). Hyperuricemia is a sign of poor prognosis for both the mother and the fetus. We investigated the relationship between uricemia and the occurrence of eclampsia in cases of severe pre-eclampsia.MATERIALS AND METHODS. This was a three-month' cross-sectional study carried out in two tertiary hospitals in the city of Yaounde; Cameroon. All patients attending the hospitals with evidence of severe pre-eclampsia or eclampsia and willing to participate in the study were enrolled. Socio-epidemiology data and blood were collected as soon as the diagnosis was made; uricemia were measured using a spectrophotometric method. Statistical analyses were performed using SPSS 18.0 and significance was observed when P was 0.05.RESULTS. Ninety five pregnant women; aged between 15 to 41 years; with evidence of severe pre-eclampsia (60) or eclampsia (35) were enrolled during the months of January to march 2015. While age below 20 years increased the risk of eclampsia (OR

Association between serum insulin and uric acid concentrations in type 2 diabetic subjects in Nigeria

Diabetic patients who are hyperuricaemic appear to be at increased risk for developing diabetic complications, renal disease, and cardiovascular disease. The present study was undertaken to determine the association between serum insulin and uric acid concentrations in individuals with type 2 diabetes and control subjects attending the University of Maiduguri Teaching Hospital (UMTH) in Nigeria. One hundred and sixty (160) subjects with an age range of 30­75 years participated in the study: 100 confirmed type 2 diabetes subjects and 60 non-diabetic controls. A significantly (p<0.05) high mean serum insulin was observed in type 2 diabetes subjects as compared with controls (9.3±2.0 vs 5.1±0.6 µlU/L). No significant difference (p>0.05) was observed in the mean serum uric acid of diabetic and control subjects (358±89 vs 334±66 µmol/L). There was a positive and significant correlation (r = 0.410; p<0.05) between serum insulin and uric acid levels in type 2 diabetes subjects. This may relate to the insulin resistance that characterises type 2 diabetes