ABSTRACT
The aim of this pilot study is to obtain preliminary results comparing topical oxygen therapy (TOT) and vacuum assisted closure (VAC) in terms of its ability to accelerate wound healing. METHODS: This non-randomised prospective study included patients with age 16-50 years, wound size ≥ 16cm2 and present below knee joint within seven days of occurrence. Bates-Jensen wound assessment tool (BWAT) was used for evaluation at 8-day interval along with percent area reduction at final follow up. RESULTS: Mean number of cycles required in VAC and TOT group were 1.97 (range 1-3) and 2.1 (range 1-3) (each cycle of 5 days) per patient respectively. Percent area reduction was significantly higher in the VAC group (34±9.7%) than TOT (11.3±3.8%) group at final follow up (p<0.05). TOT patients had better improvement in epithelialization compared to VAC at last follow up. More extensive debridement was needed in patients of TOT than VAC. There was no significant difference between final score in both groups. CONCLUSION: TOT appears to be comparable to well-established VAC in treatment of fresh traumatic wounds below the knee joint. Further large scale, multicentric and randomised studies comparing both these modalities of treatment should be the way forward
Subject(s)
Negative-Pressure Wound Therapy , Health Impact Assessment , Hyperbaric Oxygenation , Anesthetics, Local , Patients , Wound Healing , Knee JointABSTRACT
This study evaluated the effects of Nigerian Bee Propolis extract on Methicillin Resistance Staphylococcus Aureus (MRSA) infected skin wounds of albino rats. Two full thickness circular wounds were created each on the dorsum of eighteen (18) healthy adult male albino rats with mean body weight of 126±7.09g. Each wound was contaminated with 108 colony forming unit of MRSA. The rats were then randomized into three (3) treatment groups (n=6) with topical application of Propolis extract (PE Group), Silver sulphadiazine (SS Group) and untreated Control (UT Group). Gross wound healing indices (exudation, edema, hyperemia, wound contraction), histopathologic (granulation, angiogenesis, fibroplasia, epithelialization) and immunologic healing indices were evaluated using standard methods. Bacteria clearance was through culture and quantification. The wound surface exudation and edge edema and hyperemia were prominent in all the groups from day 0 to 6 but persisted in the untreated group till day 12. Wound contraction was gradual in all the groups from day 0-18, it was higher between days 0 and 3 in the PE and SS than the UT group (P<0.05). Complete wound closure occurred on SS (day 15), and PE (day 16). The histopathological changes observed showed neutrophils regressed on day 6 to 18 in all groups and was faster in PE and SS groups (P<0.05). Platelets reduction was ` gradual from days 3 to 18 in all groups and was absent from days 6 to 18 in the PE group. Nigerian Bee propolis has a profound bacteria clearance and healing effect on wound infected with methicillin resistant staphylococcus aureus (MRSA) comparable to silver sulphadiazine and therefore recommended for infected wound treatment.
Subject(s)
Humans , Wound Healing , Mucociliary Clearance , Propolis , Bees , Methicillin-Resistant Staphylococcus aureusABSTRACT
Background: Vacuum-assisted closure (VAC) therapy has been shown to be beneficial in a variety of wounds. However, evidence of its benefit in diabetic foot ulcers (DFUs), especially with respect to Indian population, is sparse. Methodology: This randomized controlled trial included DFUs of Wagner's Grades 1 and 2. Patients were further stratified with respect to DFU size <10 cm and â¥10 cm. Patients with vascular disease, osteomyelitis, and bilateral DFUs were excluded from the study. The enrolled patients were randomized to receive VAC therapy or conventional dressing. The time to wound healing, granulation tissue formation, and complications such as pain, infection, and bleeding were compared between the two groups. Results: A total of sixty patients were randomized, of which 27 in each group were analyzed. The mean time to healing in days was significantly less in VAC group (22.52 vs. 3.85; P < 0.0001). Mean time to achieve 75%100% granulation tissue cover was significantly less in VAC group (23.33 vs. 32.15; P < 0.0001). Rate of granulation tissue formation was also found to be significantly better in VAC group (2.91 cm2/day vs. 2.16 cm2/day; P = 0.0306). There was no difference between the two groups with respect to wound infection and bleeding which are commonly attributed to VAC therapy. VAC therapy group had significantly lesser pain at week 3 (Visual Analog Scale score 3 vs. 4; P = 0.004). Conclusion: VAC therapy significantly decreases the time to complete wound healing, hastens granulation tissue formation, and reduces the ulcer area compared to conventional dressing. The study did not find any significant increase in the bleeding and infection in the VAC therapy group
Subject(s)
Granulation Tissue , India , Negative-Pressure Wound Therapy , Wound HealingABSTRACT
La thérapie par pression négative ou système vacuum-assisted closure est un système non invasif qui facilite la cicatrisation des plaies. Nous avons appliqué cette technique à un patient ayant une perte de substance ilio-inguinale. Une modification de cette technique avec du matériel local a été réalisé. La cicatrisation complète a été obtenue dans un délai de neuf semaines
Subject(s)
Patients , Wound HealingABSTRACT
Burn wound colonisation and infection is not only associated with delayed wound healing and scar formation; but may also lead to sepsisrelated mortality. A wide variety of microorganisms; like staphylococcus aureus; Pseudomonas aeruginosa; and Enterobacteriaceae-like Klebsiella pneumoniae and Escherichia coli; are involved. Resistance is generally increasing; with reports of multidrug-and pan-resistant isolates. This study was conducted to determine the common aerobic bacterial isolates in our setting and describe their antimicrobial susceptibility. This retrospective; descriptive study was carried out on 243 patients; from whom 312 burn wound specimens were received by the Nelson Mandela Academic Hospital microbiology laboratory of the National Health Laboratory Service; Mthatha. All samples were processed according to standard laboratory protocols; isolates were tabulated according to age and gender of the patients; and their percentage susceptibilities to relevant antibacterials were computed. A total of 229 patient specimens showed growth on culture. The total number of isolates was 629; out of which 269 were Gram-positive cocci and 360 were Gram-negative bacilli. The commonest organism was S. aureus (27.7); followed by K. pneumoniae (13.4); Proteus mirabilis (12.4); Group D streptococcus (9.4); P. aeruginosa (8.9) and E. coli (6.2). A generally high level of resistance was observed in many organisms. Methicillinresistant S. aureus accounted for 57.5 of the S. aureus. Resistance among the Gram-negative bacilli was; in general; least to imipenem; amikacin and ciprofloxacin. The common organisms causing burn wound infections in our setting include staphylococci; Klebsiella; Proteus and Pseudomonas and there is a high level of resistance against commonly used antimicrobials. Regular surveillance of burn wound organisms and their antimicrobial resistance patterns will help in determining empirical antibiotic therapy for subsequent related septic events
Subject(s)
Bacteria , Burns , Infections , Patients , Wound Healing/mortality , Wounds and InjuriesABSTRACT
The wound healing effect of herbal ointments formulated with Napoleona imperialis (NI) embedded in different ointment bases (anionic; cationic and non-ionic) has been evaluated in vivo using the excision wound healing model; on guinea pigs. Napoleona imperialis was extracted using methanol and the extract formulated as herbal ointments. The herbal ointments were used to treat wounds inflicted onexperimental guinea pigs. The wound healing effects of the formulations were compared to that of a standard antibiotic; Cicatrinr. In all cases; there was a progressive decrease in wound area with time; indicating an efficacy of the formulations in healing the induced wounds. By the 16th day; the ointment containing 100 mg/g of Napoleona imperialis in non-ionic emulsifying ointment base showed 100
Subject(s)
Pharmaceutical Preparations , Plants , Wound HealingABSTRACT
L'objectif de ce travail est de prouver l'effet cicatrisant du nectar de kniphofia uvularia Moench (de la famille de liliacee) sur le processus de brulure du 3e. degre. L'etude a ete abordee sous l'angle d'un apport topique. Les modeles utilises sont les lapins. Il en ressort que le nectar a un effet positif sur le modele utilise