Lipid profile in HIV/AIDS patients in Nigeria

ABSTRACT

Introduction: Alterations of serum lipid profiles have been reported widely among Human Immuno deficiency Virus (HIV) positive patients on Highly Active Anti Retroviral Therapy (HAART). However; there are few data on serum lipid profile among treatment na?ve HIV positive patients in our environment. Objectives: To describe the pattern of lipid profile among treatment na?ve HIV positive patients and changes following HAART initiation. Methods: One hundred and thirty HIV positive patients seen in HIV center in an urban area in Nigeria and 44 matched individuals were recruited. Data were collected on socio demographic characters; baseline lipid profiles and CD4 count. Values of lipid parameters were retrieved after 12 months on HAART. Results: The mean Low density lipoprotein(LDL) was 2.26+ 0.9 mmol/l among the test group compared with 0.96+0.39mmol/L among the control ;p value =0.000 .The mean High density lipoprotein (HDL) was also significantly lower;0.8+ 0.6mmol/L reaching a dyslipidemic level; in the HIV positive group than the control; p value = 0.00. Tuberculosis /HIV co infected patients had a significantly elevated mean LDL; p=0.002. Conclusion: Abnormality of serum lipid is common among treatment na?ve HIV patients seen in Nigeria. The NNRTI regimen is associated with elevation of HDL and some stabilization of TC and TG