Pharmacology of absorption and distribution: optimal use of antimalarial drugs in the treatment of severe falciparum malaria in Kenya
Afr. j. health sci
; 1(1): 20-26, 1994.
Article
in English
| AIM
| ID: biblio-1256950
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ABSTRACT
Since 1989; a project at the KEMRI CRC Unit at Kilifi has focused on the design of appropriate and praticable regimens for the treatment of severe falciparum malaria. Initially; there was no data describing the absorption; distribution and elimination of quinine in Kenyan children; who constitute the great majority of patients. Pharmacokinetic studies were conducted to define these variables; which formed the basis for the design of appropriate and praticable treatment regimens. Even with optimal clinical management; the majority is high in cases of severe malaria treated with quinine at Kilifi. Alternative drugs have been studied in a search for a therapeutic regimen which will further reduce mortality
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Index:
AIM (Africa)
Main subject:
Quinine
/
Absorption
/
Malaria
/
Antimalarials
Language:
English
Journal:
Afr. j. health sci
Year:
1994
Type:
Article
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