Determination of the optimal EDTA and Pentostam concentration in the treatment of Leishmania donovani-infected laboratory animal rodent models
Afr. j. health sci
; 2(1): 254-255, 1995.
Article
in English
| AIM
| ID: biblio-1257040
Responsible library:
CG1.1
ABSTRACT
The objective of this study was to undertake a dose response study to determine the optimal Pentostam and Ethylenediamine tetraacetic acid (EDTA) dose that could be used in the treatment of leishmania-infected golden hamsters or BALB/c mice for a period of 30 days. This pilot experiment was done using only one chelator; EDTA and the toxicity results obtained from this experiment formed the basis for the selection of a suitable chelator dose of this class for the future treatment of leishmania-infected laboratory animal rodent models. It is concluded that Pentostam concentrations beyond 600 mg/kg are highly toxic to mice and therefore unsuitable for use. Although Pentostam have been used to treat leishmania-infected BALB/c mice; this study has shown that a concentration of 100 mg/KG/day is the most suitable dose for use in the treatment of rodent animal models
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Index:
AIM (Africa)
Main subject:
Leishmaniasis
/
Chelation Therapy
/
Animals
Language:
English
Journal:
Afr. j. health sci
Year:
1995
Type:
Article
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