Screening of metal ion chelators against Leishmania donovani-infected BALB/c mice

Abok, K; Anjili, C. O; Githure, J. I; Koech, D. K; Mbati, P. A; Orago, A. S

Abok, K; Anjili, C. O; Githure, J. I; Koech, D. K; Mbati, P. A; Orago, A. S.

Abok, K; s.af
Anjili, C. O; s.af
Githure, J. I; s.af
Koech, D. K; s.af
Mbati, P. A; s.af
Orago, A. S; s.af

Afr. j. health sci ; 2(1): 256-257, 1995.

Article in English | AIM | ID: biblio-1257041

Responsible library: CG1.1

ABSTRACT

ABSTRACT

Previous in vitro experiments by Mbati et al. have shown that Ethylenediamine tetraacic acid (EDTA) and Ethyleneglycol-bis (B-aminoethyl ether) N;N;N1;N1; tetraacetic acid (EGTA) substantially reduce parasite burdens of leishmania donovani in either cell free media or when engulfed in mouse peritoneal macrophages. The objective of this study was to compare the activity of the same chelators against Leishmania donovani in BALB/c mice infected with a much lower parasite inoculum

Subject(s)

Animals; Chelation Therapy; Iron Chelating Agents; Leishmaniasis; Leishmaniasis/drug therapy

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Index: AIM (Africa) Main subject: Leishmaniasis / Chelation Therapy / Iron Chelating Agents / Animals Type of study: Diagnostic study / Screening study Language: English Journal: Afr. j. health sci Year: 1995 Type: Article

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