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Evaluation of IgG antibodies against respiratory syncytial virus (RSV), and associated risk factors for severe respiratory tract infections in pre-school children in North-central, Nigeria
Faneye, Adedayo; Motayo, Babatunde O.
  • Faneye, Adedayo; s.af
  • Motayo, Babatunde O; s.af
Afr. j. infect. dis. (Online) ; 8(2): 36-39, 2014. tab
Article in English | AIM | ID: biblio-1257278
Responsible library: CG1.1
ABSTRACT

Background:

Childhood mortality and morbidity due to RSV is increasing. Our current study was aimed at determining the sero-prevalence rate of RSV IgG antibodies and investigates certain known risk factors for RSV disease severity in infants and pre-school children presenting with various forms of respiratory tract infections in Ilorin, Nigeria. Materials and

Methods:

About 280, children and 30, aged matched controls were enrolled into the study at the specialist hospital Ilorin. Blood testing for anti RSV IgG was done using a commercial ELISA kit by IVD Research Inc® Carlsbad. California U.S.A. Information regarding Nutritional status, socio-economic status and other demographic variables were collected.

Results:

A prevalence rate of 85.7% was recorded among tested children and 23.3%, in controls, across age groups and gender. A statistically significant difference in age groups were recorded among patients with LRTI, (p <0.05), age <1 41%, age 1 <5, 27.6%. This was also the case for children with SRTI (Pneumonia and Bronchiolitis), with age < 1yr, 9%, and 1 <5yr, 19.8%. Analysed risk factors for disease severity showed thatnutritional status of children were statistically significant for disease severity, p-value, 0.039 (Chi square test).

Conclusions:

We report a high level of exposure to RSV in infancy and early childhood among children from a representative population in a major central Nigerian City, further studies into neutralising antibody levels and subtype distribution of RSV are advocated
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Index: AIM (Africa) Main subject: Respiratory Syncytial Viruses / Respiratory Tract Infections / Child, Preschool / Risk Factors / Immunoglobulins, Intravenous / Child Mortality / Nigeria Type of study: Etiology study / Risk factors Country/Region as subject: Africa Language: English Journal: Afr. j. infect. dis. (Online) Year: 2014 Type: Article

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Index: AIM (Africa) Main subject: Respiratory Syncytial Viruses / Respiratory Tract Infections / Child, Preschool / Risk Factors / Immunoglobulins, Intravenous / Child Mortality / Nigeria Type of study: Etiology study / Risk factors Country/Region as subject: Africa Language: English Journal: Afr. j. infect. dis. (Online) Year: 2014 Type: Article