Evaluation of IgG antibodies against respiratory syncytial virus (RSV), and associated risk factors for severe respiratory tract infections in pre-school children in North-central, Nigeria
Afr. j. infect. dis. (Online)
; 8(2): 36-39, 2014. tab
Article
in English
| AIM
| ID: biblio-1257278
Responsible library:
CG1.1
ABSTRACT
Background:
Childhood mortality and morbidity due to RSV is increasing. Our current study was aimed at determining the sero-prevalence rate of RSV IgG antibodies and investigates certain known risk factors for RSV disease severity in infants and pre-school children presenting with various forms of respiratory tract infections in Ilorin, Nigeria. Materials andMethods:
About 280, children and 30, aged matched controls were enrolled into the study at the specialist hospital Ilorin. Blood testing for anti RSV IgG was done using a commercial ELISA kit by IVD Research Inc® Carlsbad. California U.S.A. Information regarding Nutritional status, socio-economic status and other demographic variables were collected.Results:
A prevalence rate of 85.7% was recorded among tested children and 23.3%, in controls, across age groups and gender. A statistically significant difference in age groups were recorded among patients with LRTI, (p <0.05), age <1 41%, age 1 <5, 27.6%. This was also the case for children with SRTI (Pneumonia and Bronchiolitis), with age < 1yr, 9%, and 1 <5yr, 19.8%. Analysed risk factors for disease severity showed thatnutritional status of children were statistically significant for disease severity, p-value, 0.039 (Chi square test).Conclusions:
We report a high level of exposure to RSV in infancy and early childhood among children from a representative population in a major central Nigerian City, further studies into neutralising antibody levels and subtype distribution of RSV are advocated
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Index:
AIM (Africa)
Main subject:
Respiratory Syncytial Viruses
/
Respiratory Tract Infections
/
Child, Preschool
/
Risk Factors
/
Immunoglobulins, Intravenous
/
Child Mortality
/
Nigeria
Type of study:
Etiology study
/
Risk factors
Country/Region as subject:
Africa
Language:
English
Journal:
Afr. j. infect. dis. (Online)
Year:
2014
Type:
Article
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