Study of Interleukin-18 in chronic Hepatitis C Virus related liver diseases
Afro-Egypt. j. infect. enem. Dis
; 5(1): 1-6, 2015. ilus
Article
in English
| AIM
| ID: biblio-1258740
Responsible library:
CG1.1
ABSTRACT
Background and study aim:
ELISA can determine serum Interleukin (IL)-18 level. It is a sensitive; simple and rapid test; thus help to study changes of serum IL-18 levels in chronic HCV related liver diseases during different stages. The objective of this study was to study serum IL-18 levels in chronic HCV related liver diseases. Patients andmethods:
Sera from 60 patients with HCV related chronic liver diseases at various stages of HCV infection (chronic hepatitis; cirrhosis and complications) and sera of 10 normal controls were subjected to measurements of serum IL-18 level by ELISA assay.Results:
There were highly significant increase in the mean values of serum IL-18 in chronic HCV related liver cirrhosis; non complicated and complicated patients in comparison to chronic active hepatitis C patients and healthy subjects and highly significant increase in the mean values of serum IL-18 in complicated patients in comparison to non complicated patients. There was highly significant increase in the mean values of serum IL-18 in decompensated liver cirrhosis patients when compared to compensated patients.Conclusion:
Serum IL-18 level shows highly positive significant correlation with severity of liver dysfunction in HCV related liver cirrhosis
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Index:
AIM (Africa)
Main subject:
Hepacivirus
/
Hepatitis C, Chronic
/
Liver Diseases
Language:
English
Journal:
Afro-Egypt. j. infect. enem. Dis
Year:
2015
Type:
Article
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