Oxidative stress markers and disease severity among children with sickle cell anaemia
Ann. Health Res. (Onabanjo Univ. Teach. Hosp.)
; 5(2): 193-202, 2019. ilus
Article
in English
| AIM
| ID: biblio-1258819
Responsible library:
CG1.1
ABSTRACT
Background:
Sickle cell anaemia has been associated with oxidative stress. Total Antioxidant Capacity (TAC), Total Oxidant Status (TOS) and Oxidative Stress Index (OSI) are cumulative markers of oxidative stress.Objective:
To evaluate the serum levels of oxidative stress markers in children with sickle cell anaemia (SCA) and determine the relationship between these markers and disease severity.Method:
One hundred and fifty-six children, comprising 78 with SCA, aged 1 - 15 years and 78 age- and sex-matched Haemoglobin AA controls were studied. Serum TOS, OSI, and TAC were determined using ELISA kits. The severity of the SCA was determined using clinical and laboratory parameters.Result:
Children with SCA had lower mean serum TAC (0.83±0.31UAE) than controls (1.19±0.24UAE) with p< 0.001) but positive correlation with TOS (r = 0.3, p = 0.008) and OSI (r = 0.6, p < 0.001).Conclusion:
Children with SCA had lower TAC but higher TOS and OSI than matched controls. Oxidative stress markers had a significant relationship with SCD severity
Full text:
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Index:
AIM (Africa)
Main subject:
Ascorbic Acid
/
Oxidative Stress
/
Anemia, Sickle Cell
/
Nigeria
/
Antioxidants
Country/Region as subject:
Africa
Language:
English
Journal:
Ann. Health Res. (Onabanjo Univ. Teach. Hosp.)
Year:
2019
Type:
Article
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