Insulin Resistance: Causes and Metabolic Implications
Benin J. Postgrad. Med
; 11(1): 92-96, 2009.
Article
in English
| AIM
| ID: biblio-1259592
Responsible library:
CG1.1
ABSTRACT
Insulin is an anabolic hormone that plays key roles in glucose metabolism. Insulin resistance is a decreased biological response to normal concentration of circulating insulin. In insulin resistance; normal amounts of insulin are inadequate to produce a normal insulin response from fat; muscle and liver cells. Insulin resistance in fat cells results in hydrolysis of stored triglycerides; which elevates free fatty acids in the blood plasma. In muscles; it reduces glucose uptake; whereas in the liver; it reduces glucose storage with both effects serving to elevate blood glucose. High plasma levels of Insulin and glucose due to Insulin resistance often lead to metabolic syndrome and type 2 diabetes mellitus. The cause of the vast majority of cases of insulin resistance remains unknown. However; it is claimed that insulin resistance might be caused by a high carbohydrate diet. Studies have shown that glucosamine (often prescribed for joint problems) may cause Insulin resistance. It is also reported that insulin resistance occurrence in a population increased as sugar consumption and addition of high fructose corn syrup to diets increased. Physical inactivity and obesity have been implicated as factors; which aggravate insulin resistance. The presumption that a defect in specific gene may cause insulin resistance is still under investigation
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Index:
AIM (Africa)
Main subject:
Insulin Resistance
/
Hypertriglyceridemia
/
Diabetes Mellitus
/
Insulin
/
Metabolism
Type of study:
Etiology study
Language:
English
Journal:
Benin J. Postgrad. Med
Year:
2009
Type:
Article
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