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Latent tuberculosis among adult Ethiopian patients at chest clinic, Tikuranbessa specialized hospital, Addis Ababa, Ethiopia
Bekele, Amsalu; Ashenafi, Senait; Aderay, Getachew; Assefa, Getachew; Aseffa, Abraham; Anderssen, Jan; Brighenti, Susanna.
  • Bekele, Amsalu; s.af
  • Ashenafi, Senait; s.af
  • Aderay, Getachew; s.af
  • Assefa, Getachew; s.af
  • Aseffa, Abraham; s.af
  • Anderssen, Jan; s.af
  • Brighenti, Susanna; s.af
Ethiop. med. j. (Online) ; 54(4): 181-188, 2016. ilus
Article in French | AIM | ID: biblio-1261976
Responsible library: CG1.1
ABSTRACT

Background:

One-third of the world population is infected with mycobacterium tuberculosis. Most people exposed to mycobacterium tuberculosis showed no evidence of active disease. About 5-10% of latent tuberculosis infection without HIV will progress to developed active tuberculosis in their lifetimes. This study was conducted to determine the magnitude of Latent TB among the adult population at a teaching and referral Hospital in Ethiopia.

Methods:

This study was conducted at the Chest clinic of Tikur Anbessa Specialized Hospital during 2010-2013.The study was a cross-sectional study conducted among healthy adults after informed consent was obtained from each individual. Tuberculin skin test and Interferon Gamma whole blood assay (Quantiferon-Tuberculosis-Gold) was performed using Enzyme linked Immuno-sorbent Assay. Average CD4, CD8, CD3 and CD4CD8 ratio was determined for all study participants.

Results:

From a total of 70 healthy adults tested for latent tuberculosis infection using Quantiferon Gold,45(64%) tested positive and 25 (36%) were negative for latent tuberculosis infection. From the sixty six healthy individuals who were tested using tuberculin skin test for latent tuberculosis infection, 42 (62%) individuals were Tuberculin skin test positive and 25 (38%) individuals were Tuberculin skin test negative. Average CD4, CD8, CD3 and CD4CD8 ratio was 748, 598, 1401 and 1.4, respectively.

Conclusions:

The magnitude of latent tuberculosis infection was high in this study, which reflects existing high prevalence of tuberculosis.Tuberculin skin test and Quantiferon-Tuberculosis-Goldassay show similar efficacy for the diagnosis of latent tuberculosis infection in healthy Ethiopian adults. The absolute CD4 T-cell counts of healthy HIV-negative Ethiopian's are considerably lower than other countries
Subject(s)
Full text: Available Index: AIM (Africa) Main subject: Prevalence / Cross-Sectional Studies / Adult / Ethiopia / Latent Tuberculosis / Mycobacterium tuberculosis Type of study: Observational study / Prevalence study / Risk factors Country/Region as subject: Africa Language: French Journal: Ethiop. med. j. (Online) Year: 2016 Type: Article

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Full text: Available Index: AIM (Africa) Main subject: Prevalence / Cross-Sectional Studies / Adult / Ethiopia / Latent Tuberculosis / Mycobacterium tuberculosis Type of study: Observational study / Prevalence study / Risk factors Country/Region as subject: Africa Language: French Journal: Ethiop. med. j. (Online) Year: 2016 Type: Article