Increased prevalence of activated protein C resistance during pregnancy may implicate venous thrombo embolic disorders as a common cause of maternal mortality in Nigeria
J. basic clin. reprod. sci. (Online)
; 1(1): 19-24, 2012. ilus
Article
in En
| AIM
| ID: biblio-1263393
Responsible library:
CG1.1
ABSTRACT
Background:
Acquired resistance to protein C in pregnancy has been established as one of the factors associated with thromboembolic phenomenon, an important cause of maternal mortality and morbidity.Objectives:
To establish the mean levels of PCA ratio (measure of protein C resistance) of among our pregnant women since maternal mortality rate of the country is on the increase despite efforts to reduce this trend. Materials andMethods:
A prospective study was carried out in a tertiary institution in Enugu State, Southeastern Nigeria over the 7 months period from May 2010 to November 2010. Two hundred pregnant women and 50 non pregnant female controls were recruited and PCA ratio, (coagulometric assay) were determined.Results:
There was a non significant difference between the mean and standard deviation PCA ratio of the female non pregnant controls and pregnant women in 2nd trimester 4.32±0.4 and 4.30±0.4 respectively. A significant difference was noted between the controls and pregnant women in 3rd trimester 4.32±0.4 and 3.87±0.5 respectively also between the pregnant women in their 2nd and 3rd trimester 4.30±0.4 and 3.87±0.5 respectively.Conclusion:
There is increased protein resistance C in our pregnant women. This may implicate thromboembolic disorders as one of the leading causes of increase maternal mortality despite a downward trend in the prevalence of post partum haemorrhage
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Main subject:
Pregnancy
/
Maternal Mortality
/
Protein C Deficiency
/
Venous Thromboembolism
/
Nigeria
Type of study:
Observational_studies
/
Prevalence_studies
/
Risk_factors_studies
Country/Region as subject:
Africa
Language:
En
Journal:
J. basic clin. reprod. sci. (Online)
Year:
2012
type:
Article