Occult HBV Infection among a Cohort of Nigerian Adults
J. infect. dev. ctries
; 3(6): 442-446, 2009.
Article
in English
| AIM
| ID: biblio-1263596
Responsible library:
CG1.1
ABSTRACT
Objective:
To determine markers of HBV infection and detect the presence of its occult infection in serum of a cohort of adult Nigerians.Methodology:
The study involved 28 adult Nigerians with viral hepatitis (Group 1) and 28 apparently healthy adult Nigerians as controls (Group 2). Their sera were assayed for HBsAg; HBeAg; anti-HBe; anti-HBc; anti-HBs; and anti-HCV; while HBV DNA was determined in 15 patients with chronic hepatitis. Significance of differences between the patients and control subjects was assessed using Chi-square test at a 95confidence level.Results:
Sero-detection of HBsAg; HBeAg; anti-HBe and anti-HBc was higher among the patients compared to the controls. HBV infection was diagnosed by HBsAg (89) and a duo of HBsAg and anti-HBc (100) among the patients. Similarly; eleven and four types of different patterns of HBV markers were observed among the respective groups. Anti-HBe (9.5); anti-HBc (14.3); and anti-HBs (9.5) were detected among all the subjects who were sero-negative for HBsAg. HBV DNA was also detected in 86.7of the 15 patients with chronic hepatitis; while occult HBV infection was observed in 7.2of the patients and none (0) of the controls; p 0.05. Furthermore; HCV infection occurred among subjects with all the different patterns of HBV markers; except those with occult HBV infection and natural immunity to HBV.Conclusion:
This study shows that occult HBV infection is present among Nigerian adults and determination of HBsAg; anti-HBc; anti-HBe; and HBV DNA will assist in its detection
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Index:
AIM (Africa)
Main subject:
Hepatitis B virus
/
Cohort Studies
/
Hepatitis C Antibodies
/
Adult
Type of study:
Etiology study
/
Incidence study
/
Observational study
/
Risk factors
Language:
English
Journal:
J. infect. dev. ctries
Year:
2009
Type:
Article
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