Collagen content of normal human myocardium

ABSTRACT

Hydroxyproline concentration; representing the collagen content of the normal right and left ventricular muscle in young adult Nigerians was estimated. The hydroxyproline concentration in the left ventricular muscle was lower than in the right ventricle; (Mean collagen content of right ventricle was 5.58 + 0.95 ug/mg dry weight and left ventricle 3.15 + 0.35 ug/mg dry weight). The results of this preliminary study demonstrates that changes in myocardial collagen parameters may be useful in the diagnosis of cardiac hypertrophy; heart failure; endomyocardial fibrosis or other pathogenesis of cardiac diseases in the tropics