Is there no treatment for Severe Sepsis?
Libyan Journal of Medicine
; 3(1): 1-6, 2008.
Article
in English
| AIM
| ID: biblio-1265032
Responsible library:
CG1.1
ABSTRACT
Sepsis is a systemic inflammatory response syndrome in the presence of suspected or proven infection; and it may progress to or encompass organ failure (severe sepsis) and hypotension (septic shock). Clinicians possess an arsenal of supportive measures to combat severe sepsis and septic shock; and some success; albeit controversial; has been achieved by using low doses of corticosteroids or recombinant human activated protein C. However; a truly effective mediator-directed specific treatment has not been developed yet. Treatment with low doses of corticosteroids or with recombinant human activated protein C remains controversial and its success very limited. Attempts to treat shock by blocking LPS; TNF or IL-1 were unsuccessful; as were attempts to use interferon-gamma or granulocyte colony stimulating factor. Inhibiting nitric oxide synthases held promise but met with considerable difficulties. Scavenging excess nitric oxide or targeting molecules downstream of inducible nitric oxide synthase; such as soluble guanylate cyclase or potassium channels; might offer other alternatives
Full text:
Available
Index:
AIM (Africa)
Main subject:
Protein C
/
Adrenal Cortex Hormones
/
Sepsis
/
Nitric Oxide
Language:
English
Journal:
Libyan Journal of Medicine
Year:
2008
Type:
Article
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