Adverse Effects Profile of Multidrug-Resistant Tuberculosis Treatment in a South African Outpatient Clinic
S. Afr. fam. pract. (2004, Online)
; 54(6): 531-539, 2012.
Article
in English
| AIM
| ID: biblio-1270001
Responsible library:
CG1.1
ABSTRACT
Background:
Highly active antiretroviral therapy (HAART) and drugs that are used to treat multidrug-resistant tuberculosis have potentially overlapping adverse effects. Few South African studies have documented adverse effects in the multidrugresistant tuberculosis population. This study examined the adverse effects profile in a sample of the outpatient population at the King George V Hospital Multidrug-Resistant Tuberculosis Clinic in Durban; KwaZulu-Natal.Method:
The method was an anonymous; retrospective record review of 350 patients with multidrug-resistant tuberculosis; who were attending the King George V Hospital Multidrug-Resistant Tuberculosis Clinic (2010-2011). Adverse effect profiles in patients with multidrug-resistant tuberculosis only; and those who were co-infected with the human immunodeficiency virus (HIV) who were on and not on HAART; were documented and analysed.Results:
Adverse events were recorded for 80.6 of patients. These included hearing loss (28.7); peripheral neuropathy (23.2); diarrhoea; nausea and vomiting (20.5); arthralgia (15.9); rashes and dermatological effects (excluding Stevens-Johnson syndrome) (14); abdominal pain and dyspepsia (10.3); and psychoses and confusion (8.3). In this study population; 72.6 of patients were HIV positive; and 85 were concomitantly on HAART and multidrug-resistant tuberculosis treatment. Adverse events were significantly more common in patients who were HIV positive than in patients who were HIV negative with regard to peripheral neuropathy (p-value 0.001); psychosis and confusion (p-value
Full text:
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Index:
AIM (Africa)
Main subject:
Outpatients
/
Tuberculosis
/
HIV Seronegativity
/
Coinfection
Language:
English
Journal:
S. Afr. fam. pract. (2004, Online)
Year:
2012
Type:
Article
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