The Effect of Lactose-Free Formula Feeds on Growth Responses among Severely Malnourished HIV-Infected Children in Durban; South Africa

ABSTRACT

Background. The co-occurrence of HIV infection and severe malnutrition contributes to high rates of morbidity and mortality among children in resource-limited settings. Lactose-free; ready-to-use therapeutic feeds (RUTFs) may be most appropriate in this population because of underlying mucosal damage secondary to inflammation and infection. Objectives. To describe the effect of lactose-free RUTFs on the growth parameters of severely malnourished HIV-infected children in Durban; South Africa (SA).Methods. This was a prospective; observational study of nutritional recovery in HIV-infected; severely malnourished children; aged 6 months to 5 years; who received lactose-free RUTFs following admission to King Edward VIII Hospital in Durban; SA. The primary outcome was nutritional recovery; defined as 15% weight gain from enrolment to end of study. Secondary outcomes included z-scores for weight-for-height; weight-for-age; height-for-age; triceps skinfold thickness (SFT) and subscapular SFT calculated at baseline and 7; 14; 30 and 45 days after admission. Univariate analysis was done to compare outcomes among antiretroviral therapy (ART)-naive and ART-experienced children; the effect of ART on nutritional recovery was evaluated in a logistic regression model. Results. A significant improvement in most nutritional parameters was found at 45 days; 59% of children attained nutritional recovery. There was no significant difference in the proportion of children reaching recovery based on ART status at admission (p=0.08).Conclusion. Lactose-free formula feeds may be an effective strategy for nutritional rehabilitation of severely malnourished and HIV-infected children in resource-limited settings. It remains to be determined how ART initiation affects nutritional recovery in these children