Antiemetic prophylaxis with promethazine or ondansetron in major gynaecological surgery
South. Afr. j. anaesth. analg. (Online)
; 14(6): 39-42, 2008. ilus
Article
in English
| AIM
| ID: biblio-1272228
Responsible library:
CG1.1
ABSTRACT
Background:
Postoperative nausea and vomiting remain a significant cause of morbidity among patients undergoing general anaesthesia. The optimal strategy for prevention; however; remains controversial. This study evaluated the efficacy of ondansetron 8 mg compared with promethazine 25 mg or placebo for the prevention of nausea and vomiting in patients undergoing elective major gynaecological surgery.Methods:
Seventy-five patients received intravenous injection of the study medication (ondansetron-25; promethazine-25 or placebo-25) immediately before the induction of anaesthesia. Nausea and vomiting were assessed over a 24-hour postoperative period.Results:
Nausea occurred in 20; 40and 72of the promethazine; ondansetron and placebo groups respectively (p = 0.001). The overall incidence of vomiting was 12; 16; and 60(p = 0.000) for promethazine; ondansetron and the placebo respectively. Postoperative drowsiness was prominent in the promethazine group. There was no significant difference in effectiveness between promethazine and ondansetron.Conclusions:
Promethazine 25 mg was significantly more effective than ondansetron 8 mg in the prevention of postoperative nausea and vomiting. Promethazine is inexpensive and the cost of drugs is of importance in developing African countries. Drowsiness was a significant side-effect with promethazine; and this will be a disadvantage in ambulatory surgery
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Index:
AIM (Africa)
Main subject:
Promethazine
/
Gynecologic Surgical Procedures
/
Ondansetron
/
Postoperative Nausea and Vomiting
/
Antiemetics
Type of study:
Controlled clinical trial
Language:
English
Journal:
South. Afr. j. anaesth. analg. (Online)
Year:
2008
Type:
Article
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