Radiological Changes and Progress in Patient with Pulmonary Tuberculosis Following Treatment with Daily Versus Intermittent Short Course Regimens

ABSTRACT

This is a prospective comparative randomized study carried out at Kosti teaching hospital 2006- 2008. Objectives: to determine the radiological findings and to evaluate the radiological progress in patient with pulmonary Tuberculosis treated with daily versus intermittent short course regimens. Methodology: A total of 275 smear positive new cases of Tuberculosis were enrolled and randomized in to two groups; intermittent group (A) and daily regimen group (B) .X-Ray film was done initially and at the end of treatment for each patient. Results: It was found that 31of the X-Ray films were normal. Concerning the progress of minimal lesion significantly high percentage improved to normal X-Ray 58in group A and 53in group B ; 42in group A and 40in group B stayed as minimal lesion. The results of far minimal lesion ; 8.3to moderate lesion; 33.3moderately advanced lesion and 25remained unchanged; while in the daily regimen ; 21improved to normal and minimal lesion ; 5.2to moderate lesion ; 27to moderately advanced lesion and 27.6. Statistical analysis revealed a significant difference between the two groups. Conclusion: Conversion of minimal lesions to normal X-Ray was significantly higher in the intermittent group and the conversion of far advanced lesions to normal was significantly higher in the daily regimen