Reliability of Anti-Cyclic Citrullinated Peptide Antibodies (Anti-CCP) for the Diagnosis of Rheumatoid Arthritis as Compared to that of Rheumatoid Factor Test
Sudan j. med. sci
; 6(1): 23-26, 2011.
Article
in English
| AIM
| ID: biblio-1272393
Responsible library:
CG1.1
ABSTRACT
Background:
Rheumatoid factor (RF) is commonly used for diagnosis of rheumatoid arthritis (RA). RF positivity is nonspecific for diagnosis of RA because it can be detected in 3-5of normal individuals. Recent studies indicated that anti-Cyclic-Citrullinated protein (Anti-CCP) antibodies are more specific to diagnose rheumatoid arthritis and have the capacity to diagnose RA in early stages of the disease; or even before the onset of the disease when the arthritis is undifferentiated.Objectives:
This study has been conducted to assess the reliability and specificity of anti- CCP in the Sudanese as an indicator of RA. Patients andmethods:
In this study; patients were diagnosed as RA patients according to the American College of Rheumatology (ACR) criteria. To get further insight on the sensitivity and specificity of Anti-CCP test as compared to that of RF test in the diagnosis of RA; analysis of samples obtained was perform negative rate reached 21.2. Although anti-CCP test is more accurate compared with RF; it may sometimes fail to diagnose some patients with rheumatoid antibodies were scarce
Full text:
Available
Index:
AIM (Africa)
Main subject:
Arthritis
/
Rheumatoid Factor
/
Enzyme-Linked Immunosorbent Assay
Language:
English
Journal:
Sudan j. med. sci
Year:
2011
Type:
Article
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