Chloroquine induced pruritus among patients with malaria: recent developments

ABSTRACT

The salient factors that influence the occurrence of an enhanced drug-induced itch; due to chloroquine among patients with malaria in the tropics; are presented. An overview of six relevant methods that have directly been used to investigate the problem; mainly epidemiological clinical surveys; animal and human tissue drug level analyses; an animal model of the pruritus; clinical studies; limb activity-relationship research; was performed