Leprosy in Malawi. 1. Sensitivity and specificity of the diagnosis and the search for risk factors for leprosy
Trans. R. Soc. Trop. Med. Hyg
; 82(6): 803-9, 1988.
Article
in English
| AIM
| ID: biblio-1272927
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ABSTRACT
The sensitivity and specificity of the diagnosis of leprosy in the context of a total population survey are examined. It is apparent that diagnostic tools are unsatisfactory with regard to reaching a highly sensitive and specific case definition of paucibacillary leprosy; particularly in actively found suspects. Histopathological examination of 4 mm punch biopsy specimens contributed appreciably to both the sensitivity and specificity of the diagnosis of leprosy; though there was evidence for false positive and false negative histopathology results. The needs for high sensitivity during the intake phase of a vaccine trial and for high specificity during follow-up surveys for risk factors are discussed
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Index:
AIM (Africa)
Main subject:
Leprosy
Type of study:
Diagnostic study
/
Etiology study
/
Risk factors
Language:
English
Journal:
Trans. R. Soc. Trop. Med. Hyg
Year:
1988
Type:
Article
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