Anti-ulcer and Anti-inflammatory Effects of Hydro-Alcohol Extract of Aloe buettneri A. Berger (lilliaceae)
Trop. j. pharm. res. (Online)
; 7(1): 907-912, 2008.
Article
in En
| AIM
| ID: biblio-1273093
Responsible library:
CG1.1
ABSTRACT
Purpose:
Aloe buettneri A. Berger is commonly used in Togolese folk medicine to treat inflammation and gastric ulcer. In this study we investigated the anti-oedema; analgesic; antipyretic and ulcer healing properties of the hydro-alcohol extract of their leaves.Methods:
Rat oedema paw were induced by the injection of 0.1 ml of formaldehyde 1; tail flick method is used to study analgesic property; hyperthermia was induced by subcutaneous injection of 15of a brewers' yeast suspension at dose of 10 ml/kg and ulcers were induced by ethanol or HCl/ethanol mixture.Results:
The extract showed anti-inflammatory properties at doses between 250-500 mg/kg. It inhibited; in a dose- dependent manner; the oedema induced by 0.1 ml of formaldehyde 1. Scores of 73.70and 83.63were obtned when the doses of extract administered were 100 and 500 mg/kg; respectively. The tail flick analgesic index showed an increase of 36.56when the dose was 500 mg/kg. The extract decreased significantly the hyperthermia induced by the injection of yeast. 1000 mg/kg of the extract inhibited 63.77of the gastric lesion induced by acid-water-ethanol mixture while daily administration of the same dose accele- rated the cicatrisation of gastric ulcer induced by 95ethanol.Conclusion:
The results obtained show that the hydro-alcohol extract of Aloe buettneri A. Berger (Lillia- ceae) has anti-inflammatory; anti-ulcer and wound healing properties
Full text:
1
Main subject:
Stomach Ulcer
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Plant Extracts
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Aloe
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Anti-Inflammatory Agents
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Anti-Ulcer Agents
Language:
En
Journal:
Trop. j. pharm. res. (Online)
Year:
2008
type:
Article