Evaluation of adverse drug reactions to artemisinin-based combination therapy in a Nigeria University Community
Trop. j. pharm. res. (Online)
; 7(2): 937-944, 2008. tab
Article
in English
| AIM
| ID: biblio-1273096
Responsible library:
CG1.1
ABSTRACT
Purpose:
The study was carried out to evaluate the incidence of adverse reactions to antimalarial drugs among residents of a Nigeria university community with a focus on arte- misinin-based combination therapy (ACT). Specifically; the profile of use; and the reporting culture of people with respect to experienced reactions were noted.Method:
Ques- tionnaires were administered to respondents at the university health centre between November 2006 and January 2007. Information on demographic characteristics; nature of experienced adverse reactions and the most frequently used ACT; among other questions; were collected. Descriptive statistics and Fisher's Exact test were used to evaluate the distribution of respondent's opinion.Result:
The study achieved a response rate of 86. The results revealed that 210 (70.0) of respondents said they had used artemisinin-based combination drugs while 134 (44.7) said they used artemisinin derivatives alone as monotherapy for malaria treatment. Artesunate plus amodiaquine 94 (31.3) as a co-packaged product was the most commonly used ACT. Incidence of the experienced adverse reactions to ACT was reported to be generally mild and well tolerated.Conclusion:
Efforts to improve the use of ACT in the management of acute uncomplicated P. falciparum malaria is recommended. Furthermore; an effective mechanism to improve reporting of adverse effects of ACT is also recommended
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Index:
AIM (Africa)
Main subject:
Artemisinins
/
Drug Therapy
/
Malaria
/
Antimalarials
/
Nigeria
Country/Region as subject:
Africa
Language:
English
Journal:
Trop. j. pharm. res. (Online)
Year:
2008
Type:
Article
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