Relationship between Vitamin D Levels and Outcome of Pneumonia in Children
West Afr. j. med
; 29(6): 373-378, 2010.
Article
in English
| AIM
| ID: biblio-1273498
Responsible library:
CG1.1
ABSTRACT
BACKGROUND:
Pneumonia; a common childhood infection in Nigerian children with a number of debilitating complications such as empyema thoracis; has been linked to vitamin D deficiency due to its ability to modulate the T lymphocyte of the immune system .OBJECTIVE:
To determine the relationship between vitamin D and outcome of pneumonia in children.METHODS:
This was a case-control study involving 24 children; admitted for pneumonia as subjects and 10 children without pneumonia as controls. Pre-formatted questionnaire was utilized to obtain background information; anthropometric measurements were made to determine nutritional status and estimation of 25- hydroxy cholecalciferol (25OHD) done for all those studied.RESULTS:
The mean (SD) serum 25OHD concentration was 104 (59) nmol/L and 130 (107) nmol/L for subjects and controls respectively. Amongst the subjects 15 (54) had serum 25OHD less than 70nmol/L and 11 (46) serum 25OHD greater than70nmol/L. Hypocalcaemia was present in 15 (54) of the subjects. Further analysis of hypocalcaemia with regards to the concentration of serum 25OHD showed that 2 (13) had levels below 40nmol/L; 10 (67) had levels below 70nmol/L and 3 (20) above 70nmol/L. Hypocalcaemia was more frequent among subjects with 25OHD below 70nmol/L compared with those above70nmol/L; (p = 0.01). Empyema thoracis and death occurred amongst the two subjects with 25OHD between 27.5 and 40nmol/ L. Anaemia was more frequent among subjects with 25OHD below 70nmol/L compared with those above70nmol/L (p = 0.03).CONCLUSION:
The study showed that Vitamin D insufficiency; and not solely its deficiency; may have an important role to play in the immune and haemopoetic system. It may therefore affect the response of a child to infections especially pneumonia
Full text:
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Index:
AIM (Africa)
Main subject:
Pneumonia
/
Case-Control Studies
Type of study:
Observational study
Language:
English
Journal:
West Afr. j. med
Year:
2010
Type:
Article
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