The Influence of Hyperbaric Oxygenation Therapy on Recurrent Myocardial Infarction and Two-Year Survival Rate in Acute Myocardial Infarction Patients

ABSTRACT

Background: Surgical methods of acute myocardial infarction (MI) treatment possess a high clinical effectiveness; but there are limitations; related to the patient's state; medical resources and organizational problems. The development of new medical technologies allows for a better and effective non-surgical treatment and increases long-term prognosis. Aim: To assess the influence of hyperbaric oxygenation (HBO) therapy on mortality rate and recurrent myocardial infarction (rMI) within a two-year monitoring. Methods: The study involved 129 patients who suffered from acute MI; having undergone the standard therapy. The patients were divided at random into 2 groups Group 1 (reference group; n=65); Group 2 (test group; n=64). Group 2 patients were given the traditional treatment; accompanied with (HBO) standard therapy by BLKS-307 (Russia; Moscow) single-seat apparatus (isopression for 40 minutes at a working pressure of 0.03 MPa). HBO therapy was applied on the 4th- 10th day following MI. The treatment course included 6 cycles; once per day. The clinical assessment was focused on clinical outcome: repeated MI and cardiovascular related mortality. Monitoring duration was two years. Results: The study involved 129 MI patients. No complications were encountered with HBO therapy on post-MI patients. Use of HBO reduced rMI and increased survival especially in the first half year after MI. Conclusion: HBO application that accompanied the acute MI traditional pharmacotherapy proved to reduce rMI within 2 years following inpatient discharge (the rate of rMI was 19in the reference group and 5.3in the test group; ?2=5.0; ?0.05). The joint application of HBO and modern drug regimen in treating acute MI makes it possible to raise the 2-year survival rate from 86.2up to 94.7